ArticleRadiologie (Heidelberg, Germany)2026
Predictive value of the T1-weighted signal ratio between the lumbar vertebrae and the psoas muscle in iron-deficiency anemia.
Article in Radiologie (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBone marrow reconversion is a physiological response to increased hematopoietic demand and is common in chronic anemia. Magnetic resonance imaging (MRI) enables noninvasive assessment of marrow composition; however, visual evaluation remains subjective. Because the psoas signal is largely unaffected by hematologic status, it can serve as a stable internal reference.
objectivesTo quantify lumbar vertebral marrow signal alterations in women with iron deficiency anemia (IDA) and evaluate the diagnostic performance of the T1-weighted signal ratio between the lumbar vertebrae and the psoas muscle as a predictor of anemia. MATERIALS AND
methodsThis retrospective study analyzed lumbar spine MRIs and laboratory data of 141 women (83 IDA, 58 controls). On sagittal T1-weighted images, circular regions of interest were placed in the L1 vertebral body and adjacent psoas muscle to calculate the vertebra/psoas signal ratio. Group comparisons, correlation, and receiver operating characteristic (ROC) analysis with 95% confidence intervals were performed.
resultsThe mean vertebra/psoas ratio was significantly lower in IDA (1.63 ± 0.34) than in controls (2.19 ± 0.71; p < 0.001). Hemoglobin levels correlated positively with the ratio (β = 0.11; R
conclusionThe lumbar vertebra/psoas T1-weighted signal ratio is significantly reduced in IDA and correlates with hemoglobin levels. It represents a simple and reproducible quantitative MRI biomarker that may aid in the screening and diagnostic evaluation of anemia on routine spine imaging.
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