Evidence map›Paper›PMID 42704035›Full record

ArticleRadiology and oncology2026

EPHA3, upregulated in high-risk histological subtypes of gastrointestinal stromal tumor, promotes GIST progression.

Han Wei, Jia Zhao, Hongmei Wang, Lihong Guo, Yanhong Liu, Chuntao Wang, Liang Yang, Zhi Qi, Wencong Tian, Lei Cao and 1 more

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Article in Radiology and oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Han Wei1Department of Molecular Pharmacology, School of Medicine, Nankai University; Tianjin, 300071, China.
Jia Zhao2Department of General Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Nankai University, Tianjin, 300122, China.
Hongmei Wang1Department of Molecular Pharmacology, School of Medicine, Nankai University; Tianjin, 300071, China.
Lihong Guo3Institute of Digestive Disease, Shengli Oilfield Central Hospital, Dongying, 257000, China.
Yanhong Liu2Department of General Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Nankai University, Tianjin, 300122, China.
Chuntao Wang2Department of General Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Nankai University, Tianjin, 300122, China.
Liang Yang1Department of Molecular Pharmacology, School of Medicine, Nankai University; Tianjin, 300071, China.
Zhi Qi1Department of Molecular Pharmacology, School of Medicine, Nankai University; Tianjin, 300071, China.
Wencong Tian2Department of General Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Nankai University, Tianjin, 300122, China.
Lei Cao2Department of General Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Nankai University, Tianjin, 300122, China.
Yang Gao1Department of Molecular Pharmacology, School of Medicine, Nankai University; Tianjin, 300071, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo explore the expression pattern and functional role of EPH receptor A3 (EPHA3) in high-risk gastrointestinal stromal tumors (GISTs) and its potential relevance to tumor progression. MATERIALS AND

methodsImmunohistochemical (IHC) analysis was performed to evaluate EPHA3 expression across a pilot cohort of clinical GIST specimens with different risk stratifications. The biological functions of EPHA3

resultsEPHA3 expression was found to be elevated in high-risk GIST specimens compared with intermediate-risk cases. Loss-of-function assays demonstrated that EPHA3 knockout attenuated cell proliferation and migration while promoting apoptosis

conclusionsOur findings suggest that EPHA3 is upregulated in high-risk GIST and contributes to aggressive cellular behavior

Indexed as

Gastrointestinal NeoplasmsGastrointestinal Stromal TumorsReceptor, EphA3ApoptosisCell MovementCell ProliferationDisease ProgressionFemaleHumansImmunohistochemistryPilot ProjectsUp-RegulationEPHA3 protein, humanReceptor, EphA3EPHA3epithelial–mesenchymal transition (EMT)gastrointestinal stromal tumors (GISTs)histological subtype

Identifiers

PMID42704035
PMCPMC13548678

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.