Evidence map›Paper›PMID 42703812›Full record

ArticleInternational journal of fertility & sterility2026

Role of Epigenetic Modifications in The Aberrant Expression of The

Samaneh Chegeni, Raha Favaedi, Saeed Irian, Niloofar Bajool, Fariba Ramezanali, Gilda Karimi, Elham Amirchaghmaghi, Maryam Shahhoseini

Abstract read
In one paragraph

Article in International journal of fertility & sterility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samaneh ChegeniDepartment of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Raha FavaediDepartment of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Saeed IrianDepartment of Cellular & Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
Niloofar BajoolDepartment Cell and Molecular Biology, College of Bio Science, Islamic Azad University North Tehran Branch, Tehran, Iran.
Fariba RamezanaliDepartment of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Gilda KarimiDepartment of Cellular & Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
Elham AmirchaghmaghiDepartment of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Email: e.amirchaghmaghi@royan-rc.ac.ir.
Maryam ShahhoseiniDepartment of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Email: m.shahhoseini@royan-rc.ac.ir.ORCID 0000-0002-9021-6408

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Various studies have reported aberrant function of the immune system in endometriosis. This highly prevalent disease can initiate and progress by numerous genetic and epigenetic alterations that affect immune system functions. Regulatory T cells (Treg) play an important role in controlling and prevention of endometriosis through regulating immune responses. Treg cells are regulated by the forkhead box P3 ( Materials and Methods: In the current case-control study, endometriotic tissues of women diagnosed with endometriosis (n=20) were compared with non-endometriotic women (n=20). Parallel to expression of this gene, chromatin immunoprecipitation (ChIP) coupled with real-time polymerase chain reaction (PCR) was used to quantify the incorporated levels of the epigenetic activating/repressing markers of H3K9ac/me2 into the Results: There was a significant reduction of Conclusion: Downregulation of

Indexed as

EndometriosisEpigeneticFOXP3Histone Modification

Identifiers

PMID42703812
PMCPMC13535263

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.