Observational studyBehavioural neurology2026
Alterations in Corpus Callosum Subregion Microstructure Associated With Visual Dysfunction in Individuals With Cerebral Visual Impairment.
Observational study in Behavioural neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Alterations in Corpus Callosum Subregion Microstructure Associated With Visual Dysfunction in Individuals With Cerebral Visual Impairment.Behavioural neurology · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundCerebral/cortical visual impairment (CVI) is among the leading causes of visual impairment in children. Yet, identifying the neural correlates of CVI remains challenging due to the heterogeneous underlying etiologies and visual manifestations. While previous work has focused on intra-hemispheric white matter connections, in this cross-sectional observational study, we focus on the potential contribution of inter-hemispheric white matter connections via the corpus callosum (CC) to the severity of visual dysfunction in individuals with CVI.
methodsSeven segments of the CC were isolated in 21 participants with CVI (10 M, 11 F, mean age: 20.19 years, 8.38 s.d., range: 10-44 years) and 26 controls (10 M, 16 F, mean age: 19.00 years, 5.82 s.d., range: 10-28 years) without a history of brain injury or visual impairment. Mixed models were used to investigate within- and between-group differences in diffusion metrics. Associations between diffusion metrics of the CC segments and severity of visual dysfunctions across five domains determined by the CVI Questionnaire were calculated in an exploratory analysis within the CVI group.
resultsSignificantly lower fractional anisotropy (FA) and higher radial diffusivity (RD) measures were observed for isthmus and splenium, as well as higher mean diffusivity (MD) for the splenium in the CVI group compared with control following correction for multiple comparisons. In our exploratory analysis, the severity of impairments in object and face processing, impairments moving in space, and anxiety-related behaviors were significantly negatively associated with diffusion properties of posterior midbody CC segments in the CVI group. Additional positive correlations between visual disinterest and AD of the rostrum were also observed.
conclusionsOur results demonstrate that while CVI is associated with atypical diffusion properties in the posterior portions of the CC, the severity of visual dysfunctions may be associated with underlying tissue composition of the anterior and mid-posterior segments of the CC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.