ArticleOpen forum infectious diseases2026
Retrospective Analysis of Chronic Q Fever Cases at a Tertiary Care Center From 2007 to 2023.
Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic Q fever, caused by Methods: We conducted a retrospective cohort study of chronic Q fever cases at the Mayo Clinic from 2007 to 2023. Patients with clinical evidence and a phase I IgG titer ≥1:1024 and/or positive polymerase chain reaction for Results: We identified 33 patients with chronic Q fever (median age 56; 88% male). Median time to diagnosis was 99 days, with 11.4 days between infectious diseases evaluation and diagnosis. Animal exposure was reported in 17 patients (52%), while 8 (24%) had no identifiable exposure. Patients primarily presented with prosthetic valve endocarditis ( Conclusions: Chronic Q fever remains under-recognized, with substantial diagnostic delays prior to treatment. Cardiovascular infection predominates, and surgical intervention is often required despite prolonged antimicrobial therapy. Early specialist evaluation and standardized diagnostic pathways may improve outcomes.
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