ArticleInternational journal of general medicine2026
The Relationship Between Left Atrial Epicardial Adipose Tissue Volume and Coronary Microvascular Dysfunction in Patients with Non-Obstructive Coronary Artery Disease.
Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate whether epicardial adipose tissue (EAT) volume correlates with coronary microvascular dysfunction (CMD) identified via invasive physiological evaluation, in comparison with EAT attenuation. Materials and Methods: This retrospective study included 158 consecutive patients (mean age 65.40±9.76 years, 51.90% male) who underwent both coronary computed tomography angiography (CCTA) and invasive coronary function testing. CMD was defined as coronary flow reserve (CFR) <2.0 and/or index of microcirculatory resistance (IMR) ≥25. Total EAT volume, left atrial (LA)-EAT volume, and right atrial (RA)-EAT volume, EAT attenuation, and coronary fat attenuation index (FAI) were quantified from CCTA images. Multivariable logistic regression analyses were performed to screen variables associated with CMD. Results: CMD was diagnosed in 59 patients (37.34%). Patients with CMD had significantly higher total EAT volume, LA-EAT volume, and RA-EAT volume (all Conclusion: Total and atrial-specific EAT volumes, particularly LA-EAT volume, are strongly and independently associated with CMD, whereas FAI shows no association with coronary microvascular dysfunction. EAT volume measurements acquired from routine CCTA may act as a valuable imaging biomarker for CMD-related risk stratification. LA-EAT measurement obtained from routine CCTA is promising for convenient clinical screening of coronary microvascular dysfunction.
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