ArticleCureus2026
Palmar Neurofibromas Radiologically Mimicking Lipomas: A Case Series of Surgical Pitfalls and the Role of Immunohistochemistry.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Palmar neurofibromas are rare peripheral nerve sheath tumors (PNSTs) that can radiologically mimic lipomas, posing a risk of unanticipated nerve injury during excision and creating diagnostic and surgical challenges. A retrospective analysis of prospectively maintained data from three consecutive patients with histopathologically confirmed palmar neurofibromas treated between 2017 and 2025 was performed after institutional ethical approval. Two female and one male patient, aged 28-68 years, presented with progressively enlarging and painful palmar swellings. Preoperative ultrasonography and/or magnetic resonance imaging suggested lipomatous lesions in all cases. All patients underwent magnification-assisted nerve-sparing excision, and histopathological evaluation supplemented with immunohistochemical markers, including S-100, SOX10, CD34, and Ki-67, established the diagnosis of neurofibroma in each case. Intraoperatively, a neural origin was identified in all lesions. Meticulous microsurgical interfascicular dissection was carried out to preserve nerve continuity. Despite misleading radiological appearance, complete excision with preservation of the involved nerves was achieved in all patients. During follow-up ranging from one to eight years, no recurrences were observed; one patient experienced transient postoperative digital numbness that resolved completely within three months. Palmar neurofibromas are uncommon lesions that may be difficult to distinguish from lipomas on imaging, and definitive diagnosis relies on histopathological examination supported by targeted immunohistochemistry to differentiate them from schwannoma, lipoma, and malignant PNSTs. Heightened preoperative suspicion, appropriate patient counseling, meticulous microsurgical technique, and nerve-sparing surgery are essential for optimizing functional outcomes. Surgeons should maintain a high index of suspicion for neural tumors when evaluating palmar soft-tissue masses with apparently benign lipomatous imaging characteristics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.