ArticleIranian journal of basic medical sciences2026
High-intensity interval training attenuates neuroinflammation and seizure activity via miR-146a/NF-κB signaling in chronic mesial temporal lobe epilepsy.
Article in Iranian journal of basic medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Regular exercise training has emerged as a non-pharmacological approach that can beneficially impact disease progression in epileptic patients, but the underlying molecular pathways remain unclear. In this study, we investigated the effects of eight weeks of high-intensity interval training (HIIT), recognized as a time-efficient form of aerobic exercise, on hippocampal neuroinflammation and seizure activity in a kainic acid rat model of chronic Mesial temporal lobe epilepsy (MTLE). Materials and Methods: After induction of epilepsy via intrahippocampal injection of kainic acid, rats were randomly divided into 4 groups: Control, Sham, Epilepsy, and Epilepsy+HIIT. After an acclimatization period, rats in the exercise group performed 8 weeks of HIIT. The HIIT protocol consisted of running at 90% of Vmax, with active rest periods at 30% of Vmax. At the end of week 8, rats were sacrificed, and hippocampal tissue was extracted for Western blotting and real-time qPCR. Results: After 8 weeks of HIIT, our data showed that IL-1β ( Conclusion: Our results indicate that HIIT could serve as a potent anti-inflammatory and neuroprotective tool in chronic MTLE through regulating the miR-146a/NF-κB/pNMDA pathway, highlighting that regular chronic exercise training could be a complementary therapeutic option for drug-resistant epilepsy.
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