Evidence map›Paper›PMID 42703254›Full record

ArticleOrthopaedic journal of sports medicine2026

No Added Benefit of Nonsteroidal Anti-Inflammatory Drug Prophylaxis Beyond 15 Days for Heterotopic Ossification After Hip Arthroscopy.

Muge Kirac, Tahir Koray Yozgatlı, Rauf Alizada, Enis Yildirim, Gokhan Polat, Asim Kayaalp, Baris Kocaoglu

Abstract read
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Article in Orthopaedic journal of sports medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Muge KiracDepartment of Orthopedics and Traumatology, Acibadem Mehmet Ali Aydinlar University, School of Medicine, Istanbul, Turkey.ORCID https://orcid.org/0009-0005-5615-7087
Tahir Koray YozgatlıDepartment of Orthopedics and Traumatology, Acibadem Mehmet Ali Aydinlar University, School of Medicine, Istanbul, Turkey.
Rauf AlizadaDepartment of Orthopedics and Traumatology, Cankaya Hospital, Ankara, Turkey.
Enis YildirimDepartment of Orthopedics and Traumatology, Konak Hospital, Kocaeli, Turkey.
Gokhan PolatDepartment of Orthopedics and Traumatology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Asim KayaalpDepartment of Orthopedics and Traumatology, Cankaya Hospital, Ankara, Turkey.
Baris KocaogluDepartment of Orthopedics and Traumatology, Acibadem Mehmet Ali Aydinlar University, School of Medicine, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-2537-0660

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Heterotopic ossification (HO) is a well-known postoperative complication of hip arthroscopy that can lead to pain, limited range of motion, and, in advanced cases, the need for revision surgery. Nonsteroidal anti-inflammatory drugs (NSAIDs), including diclofenac and indomethacin, are widely used for HO prophylaxis. However, there is no consensus on the optimal agent, dosage, and duration of administration. Hypothesis/Purpose: This study aims to compare the efficacy of diclofenac and indomethacin administered for different durations in preventing HO after hip arthroscopy and to evaluate the impact of varying treatment regimens on postoperative clinical outcomes. It was hypothesized that both diclofenac and indomethacin would effectively prevent HO, with no significant difference in HO incidence between them or with prolonged treatment. Study Design: Cohort study; Level of evidence, 3. Methods: A retrospective, multicenter study included 1084 patients who underwent hip arthroscopy for femoroacetabular impingement (FAI) between January 2017 and December 2024. Patients were categorized according to the prophylaxis protocol administered: diclofenac 75 mg for 15 days or indomethacin 75 mg for 15, 30, or 45 days daily. The presence and grade of HO were evaluated according to the Brooker classification. Functional outcomes were assessed pre- and 3, 6, 9, and 12 months postoperatively using the visual analog scale for pain (VAS-Pain) and the Hip Outcome Score-Activities of Daily Living (HOS-ADL). Results: No significant difference in HO development was observed among the study groups ( Conclusion: The incidence and severity of HO did not differ significantly among diclofenac and indomethacin prophylaxis regimens after hip arthroscopy. Prolonging indomethacin prophylaxis beyond 15 days was not associated with a lower rate of HO. These findings suggest that longer NSAID prophylaxis protocols may not provide additional benefit for HO prevention compared with shorter regimens.

Indexed as

diclofenacfemoroacetabular impingementheterotopic ossificationhip arthroscopyindomethacinnonsteroidal anti-inflammatory drugs prophylaxis

Identifiers

PMID42703254
PMCPMC13546430

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.