Evidence map›Paper›PMID 42703176›Full record

ReviewMicroRNA (Shariqah, United Arab Emirates)2026

An Insight into the Emerging Role of Extracellular Vesicle-derived Noncoding RNAs in Colorectal Cancer.

Vijayalakshmi Jayaraman, Soniga Apthi, Liza Datta, Kanagaraj Palaniyandi, Dhanavathy Gnanasampanthapandian

Abstract readReview
PubMed Publisher
In one paragraph

Review in MicroRNA (Shariqah, United Arab Emirates), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vijayalakshmi JayaramanCancer Science Laboratory, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chengalpatu District, Chennai, Tamil Nadu, 603203, India.
Soniga ApthiCancer Science Laboratory, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chengalpatu District, Chennai, Tamil Nadu, 603203, India.
Liza DattaCancer Science Laboratory, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chengalpatu District, Chennai, Tamil Nadu, 603203, India.
Kanagaraj PalaniyandiCancer Science Laboratory, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chengalpatu District, Chennai, Tamil Nadu, 603203, India.
Dhanavathy GnanasampanthapandianCancer Science Laboratory, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chengalpatu District, Chennai, Tamil Nadu, 603203, India.ORCID 0000-0003-3708-0481

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) ranks among the most frequent and lethal cancers globally, with early detection remaining a significant challenge because of asymptomatic early stages and limitations of current screening methods. This underscores the pressing need for new, non-invasive biomarkers for early CRC detection to enhance patient outcomes. Advancements in the molecular biology of cancer have highlighted the importance of non-coding RNAs (ncRNAs) in the genesis and progression of CRC. Exosomal non-coding RNAs (ncRNAs), microRNAs (miRNAs), circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs) have shown promise in this regard. These molecules, carried by small extracellular vesicles known as exosomes, are key players in cell communication and have been associated with the regulation of essential cancer pathways, including cell proliferation, metastasis, and drug resistance. This review discusses the potential of exosomal ncRNAs as innovative biomarkers and therapeutic targets in CRC. This study covers their role in cancer biology, the challenges in their application, and future directions for leveraging these ncRNAs to advance CRC diagnosis and treatment. Exploring exosomal ncRNAs opens new avenues for enhancing CRC management through early detection and targeted therapy, potentially transforming oncology patient care.

Indexed as

Colorectal NeoplasmsExtracellular VesiclesRNA, UntranslatedAnimalsBiomarkers, TumorExosomesGene Expression Regulation, NeoplasticHumansMicroRNAsRNA, CircularRNA, Long NoncodingBiomarkers, TumorMicroRNAsRNA, CircularRNA, Long NoncodingRNA, UntranslatedcircRNAscolorectal cancerExosomeslncRNAsmicroRNAsnon-coding RNAs

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.