ArticleLuminescence : the journal of biological and chemical luminescence2026
A Noncovalent Fluorescent Probe for Dynamic Monitoring of Hemoglobin Accumulation in Living Cells.
Article in Luminescence : the journal of biological and chemical luminescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Dynamic assessment of intracellular hemoglobin (Hb) levels enables a deeper understanding of Hb-induced cytotoxicity, supports the evaluation of disease progression, and informs the development of targeted therapeutic strategies. However, traditional Hb detection methods typically require cell lysis or tissue fixation, which precludes the observation of dynamic processes in living cells. Herein, we reported a noncovalent fluorescent probe, DMBM, which enabled the dynamic monitoring of bovine hemoglobin (BHb) accumulation in living cells. DMBM exhibited strong intrinsic fluorescence and demonstrated a significant selective quenching response toward BHb (LOD = 0.23 μM). This specific fluorescence response originated from noncovalent interactions between DMBM and BHb, as evidenced by the significant fluorescence recovery observed upon BHb denaturation induced by high concentrations of urea. Furthermore, DMBM possessed a strong binding affinity for BHb (K
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