Observational studyRisk analysis : an official publication of the Society for Risk Analysis2026
Acceptance of the COVID-19 Booster Vaccine Amid the Omicron JN.1 Surge in Southern Bangladesh: A Comparative Analysis of Rural-Urban Disparities.
Observational study in Risk analysis : an official publication of the Society for Risk Analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Rapid spread of SARS-CoV-2 variants, including Omicron JN.1, has revived significant challenges to health systems and regenerates microbial risk to public health security. Although COVID-19 booster vaccines have ensured enhanced protection against new variants, there remain persistent disparities in vaccine acceptance and uptake between rural and urban populations. This study assesses COVID-19 booster vaccine acceptance and compares antecedents of acceptance across rural and urban communities in Southern Bangladesh. A cross-sectional observational study was conducted between December 15, 2023, and March 15, 2024, in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. By using stratified random sampling, 707 adults comprising 379 rural and 328 urban respondents (refusal rate: 16.7% rural, 23.2% urban) were surveyed. The study employed descriptive statistics and binary logistic regression analysis to identify socio-psychological predictors of booster acceptance, with statistical significance set at p < 0.05. The acceptance rate of COVID-19 vaccine booster dose was 69.9% overall, with a significantly lower rate in rural 62.5% (95% CI: 60.6-64.8) compared to urban areas 78.4% (95% CI: 76.2-80.6, χ
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