ArticleCNS neuroscience & therapeutics2026
Choroid Plexus Microstructural Alterations Link Glymphatic Dysfunction and White Matter Degeneration in Parkinson's Disease.
Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
objectivesGlymphatic dysfunction is increasingly recognized as a key contributor to the progression of Parkinson's disease (PD). In PD, both choroid plexus (CP) alterations and white matter abnormalities have been linked to glymphatic dysfunction. However, how CP microstructural abnormalities relate to glymphatic function, corpus callosum (CC) degeneration, and clinical impairment remains unclear. This study aimed to investigate these associations in PD.
methodsEighty-one patients with idiopathic PD and eighty age- and sex-matched healthy controls (HC) underwent MRI scanning. CP microstructural metrics (free water [FW], FW-corrected fractional anisotropy [FA
resultsPatients with PD showed significantly higher CP FW and MD
conclusionsCP microstructural abnormalities were associated with DTI-ALPS alterations, CC degeneration, and clinical impairment in PD. FW-DTI metrics of the CP may provide useful imaging markers for characterizing CP-related changes in PD.
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