ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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13 authors.
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Abstract
Mesenchymal stem cells (MSCs) are critical for bone regeneration, and their osteogenic and adipogenic lineage balance is intricately regulated by cellular mechanotransduction. Through single-cell RNA sequencing reanalysis of the public dataset GSE166824, primary mouse MSC functional assays, and in vivo genetic and bone defect models, this study identifies a novel PIEZO1/specificity protein 1 (SP1)/stanniocalcin 2 (STC2) signaling axis that drives matrix stiffness-dependent MSC lineage commitment. Stiff matrices robustly direct MSCs toward osteogenic differentiation while inhibiting adipogenesis by activating the mechanosensitive ion channel PIEZO1. PIEZO1 activation triggers Ca
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