ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
A Preclinical Multifunctional Capsule Robot with Unified Diagnosis and Targeted Thermal Therapy for Gastrointestinal Diseases.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Capsule endoscopes play an essential role in visualizing the gastrointestinal tract and identifying pathological lesions, but existing systems are still largely limited to passive visualization without therapeutic capability. Here, we present a proof-of-concept multifunctional capsule robot (MCR) integrating diagnostic imaging, magnetic navigation, wireless power transfer, and targeted thermotherapy. In the ex vivo environment, the MCR relies on magnetic navigation and control to position itself at the target site. This enables site-specific thermal ablation, where controlled high temperatures are applied within the tissue to achieve substantial cellular destruction. These results support the feasibility of the prototype's intended functions. Through a series of in vitro cellular experiments, the MCR further demonstrated controllable temperature regulation, achieving up to 89% cell mortality under 70
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