Evidence map›Paper›PMID 42702831›Full record

ReviewXenotransplantation

Blastocyst Complementation: The New Kid on the Xenotransplantation Block.

Mark B Nottle, Peter J Cowan, Wayne J Hawthorne

Abstract readReview
In one paragraph

Review in Xenotransplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mark B NottleRobinson Research Institute and School of Pharmacy and Biomedical Science, Adelaide University, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0001-7625-5542
Peter J CowanImmunology Research Centre, St. Vincent's Hospital, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0001-9016-4954
Wayne J HawthorneTranslational Transplantation Therapies Program, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.ORCID https://orcid.org/0000-0001-8638-3468

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transplantation of genetically modified pig organs and tissues is arguably the most promising approach to overcoming the world-wide shortage of organ and tissues for transplantation. The advent of gene editing has seen a resurgence in interest in this approach which has also allowed blastocyst complementation to be explored as an alternative to solving this challenge. Genetic strategies are increasingly being used to explore this possibility and overcome the many scientific hurdles this presents. While blastocyst complementation faces many scientific challenges the ethical questions surrounding this approach are equally important and will need to be addressed at the same time, if this new kid on the xenotransplantation block is to become a reality.

Indexed as

BlastocystTransplantation, HeterologousAnimalsAnimals, Genetically ModifiedGene EditingHeterograftsHumansSwineblastocyst complementationembryogene editingpluripotent stem cellsxenotransplantation

Identifiers

PMID42702831
PMCPMC13547639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.