Evidence map›Paper›PMID 42702821›Full record

ArticleGut microbes2026

Determinants of enteric hyperoxaluria in the SAMP1/YitFc mouse model of spontaneous ileitis.

Nadim Zaidan, Karim Jaber, Melody Ho, Boyan Zhou, Zhiheng Pei, Michelle L Bui, Lila Cardozo, Kyle Merritts, Rashmi Mishra, Xiaozhong Xiong and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nadim ZaidanDivision of Nephrology, Department of Medicine, NYU Langone Health, New York, NY, USA.
Karim JaberDivision of Nephrology, Department of Medicine, NYU Langone Health, New York, NY, USA.ORCID 0000-0001-5986-5576
Melody HoDivision of Nephrology, Department of Medicine, NYU Langone Health, New York, NY, USA.
Boyan ZhouDivision of Biostatistics, Department of Population Health, NYU Langone Health, New York, NY, USA.
Zhiheng PeiDepartment of Pathology, NYU Langone Health, VA Hospital, New York, NY, USA.
Michelle L BuiDepartment of Urology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Lila CardozoDivision of Nephrology, Department of Medicine, NYU Langone Health, New York, NY, USA.
Kyle MerrittsDivision of Nephrology, Department of Medicine, NYU Langone Health, New York, NY, USA.
Rashmi MishraDivision of Nephrology, Department of Medicine, NYU Langone Health, New York, NY, USA.
Xiaozhong XiongDivision of Nephrology, Department of Medicine, NYU Langone Health, New York, NY, USA.
Yeji KimDivision of Biostatistics, Department of Population Health, NYU Langone Health, New York, NY, USA.
Ming WuDepartment of Pathology, Hofstra/Northwell Zucker School of Medicine, Lake Success, NY, USA.
John KnightDepartment of Urology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Sonia FargueDepartment of Urology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Huilin LiDivision of Biostatistics, Department of Population Health, NYU Langone Health, New York, NY, USA.
Lama NazzalDivision of Nephrology, Department of Medicine, NYU Langone Health, New York, NY, USA.

Funding

Comprehensive Analysis of Oxalate Homeostasis in Calcium Oxalate Kidney Stone FormersR01DK137784 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Sonia Fargue · 2024 to 2026
$1.9M
Gut-kidney axis in enteric hyperoxaluriaR01DK129675 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NAZZAL, LAMA · 2021 to 2025
$1.7M
NIDDK NIH HHS R01 DK129675NIDDK NIH HHS R01 DK137784
6 · The paper itself

Abstract

Enteric hyperoxaluria (EH) results from increased oxalate bioavailability in the gastrointestinal (GI) tract, often affecting patients with inflammatory bowel disease (IBD). We investigated the pathophysiology of EH in an ileitis mouse model, hypothesizing that fat malabsorption, increased gut permeability, and microbial shifts collectively contribute to the hyperoxaluric phenotype in the setting of GI tract inflammation. SAMP1/YitFc (SAMP1) mice and their parental AKR controls were fed one of three diets varying in fat content (10%, 45%, or 60% kcal), each supplemented with 1% oxalate, for 6 weeks. Plasma (P), urine (U), oxalate (Ox), and creatinine (Cr) levels were measured, while stool lipid species were analyzed using mass spectrometry. Intestinal permeability was assessed using sucralose and

Indexed as

HyperoxaluriaIleitisAnimalsBacteriaDiet, High-FatDisease Models, AnimalFecesGastrointestinal MicrobiomeIleumIntestinal Barrier FunctionKidneyMaleMiceMice, Inbred AKROxalatesPermeabilityOxalateschronic kidney diseaseenteric hyperoxaluriaGut microbiomeileitismalabsorptionpermeability

Identifiers

PMID42702821
PMCPMC13556960

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.