Evidence map›Paper›PMID 42702812›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Antigen-Detected NMR for Minimal Epitope Engineering and Structure-Guided Selection of a Na

Junyu Liu, Wanlin Chen, Ben Cristofori-Armstrong, Theo Crawford, Kai-En Chen, Peng Xie, Rainbow Wing Bo Chan, Yifei Zhu, Mimi Golder, Anneka Pereira Schmidt and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Junyu LiuAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0002-8926-0161
Wanlin ChenInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0001-7103-9170
Ben Cristofori-ArmstrongAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0003-0235-2029
Theo CrawfordAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia.
Kai-En ChenInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0003-1106-1629
Peng XieCentre for Biomedical Technologies, Faculty of Engineering, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID https://orcid.org/0009-0008-8537-6643
Rainbow Wing Bo ChanThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Yifei ZhuAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0003-3964-0120
Mimi GolderAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia.
Anneka Pereira SchmidtAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia.
Jennifer D NaughtonAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia.
Nicholas D CondonInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0002-1833-1129
Åsa AnderssonInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.
Farhad DehkhodaSchool of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0002-6485-9952
Kirsten L McMahonInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.
Tabea KlasfausewehInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0002-0890-7403
Ashvriya ThapaInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.
Hue TranInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.
Poanna TranInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0003-3196-9896
Sina JamiInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0001-7134-7448
Lotten RagnarssonInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0002-7137-1656
Sebastian G B FurnessSchool of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0001-8655-8221
Jennifer R DeuisInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.
Brett M CollinsInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0002-6070-3774
Wai-Hong ThamThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID https://orcid.org/0000-0001-7950-8699
Indira PrasadamCentre for Biomedical Technologies, Faculty of Engineering, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0001-5057-2427
Irina VetterInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.
Mehdi MobliAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0003-2420-4262

Funding

Australian Research Council DE240101233Australian Research Council DP190101177Australian Research Council DP240102097Chan Zuckerberg Initiative 2023-329684National Health and Medical Research Council APP1034958National Health and Medical Research Council APP1080405National Health and Medical Research Council APP1102267National Health and Medical Research Council APP2016410National Health and Medical Research Council GNT2016908
6 · The paper itself

Abstract

Selective molecular recognition of membrane proteins is challenging because they contain few solvent-exposed extracellular epitopes, which often depend on their native environment for structure, making them difficult to isolate faithfully for binder discovery. Here, we show that antigen-detected NMR is well suited both to characterizing the folding of engineered minimal epitopes from the human voltage-gated sodium channel Na

Indexed as

chondrocytesnanobodyNaV1.7NMR spectroscopyprotein binder

Identifiers

PMID42702812
PMCPMC13547701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.