Evidence map›Paper›PMID 42702804›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Increased Disarray of Extracellular Matrix Collagen-I Fiber Network and Compromised Biomechanics in Aortae From Marfan-Syndrome Mice Assessed Through Combined Opto-Biomechatronics.

Dominik Schneidereit, Anika Nagel, Vanessa I T Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H Wagner and 1 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dominik SchneidereitInstitute of Medical Biotechnology, Department of Chemical and Biological Engineering, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Anika NagelInstitute of Physiology and Pathophysiology, Ruprecht-Karls University Heidelberg, Heidelberg, Germany.
Vanessa I T ZwaansInstitute of Physiology and Pathophysiology, Ruprecht-Karls University Heidelberg, Heidelberg, Germany.ORCID https://orcid.org/0009-0009-8480-3911
Laureen SchurrInstitute of Medical Biotechnology, Department of Chemical and Biological Engineering, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Jonas AhrInstitute of Medical Biotechnology, Department of Chemical and Biological Engineering, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Michael HaugInstitute of Medical Biotechnology, Department of Chemical and Biological Engineering, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.ORCID https://orcid.org/0000-0001-5968-2593
Anna PilusoInstitute of Physiology and Pathophysiology, Ruprecht-Karls University Heidelberg, Heidelberg, Germany.
Alexandra SporkovaInstitute of Physiology and Pathophysiology, Ruprecht-Karls University Heidelberg, Heidelberg, Germany.
Matthias KarckDepartment of Cardiac Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Andreas H Wagner *Institute of Physiology and Pathophysiology, Ruprecht-Karls University Heidelberg, Heidelberg, Germany.ORCID https://orcid.org/0000-0003-2723-5953
Oliver Friedrich *Institute of Medical Biotechnology, Department of Chemical and Biological Engineering, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.ORCID https://orcid.org/0000-0003-2238-2049

Funding

German Research Foundation WA 1511/3-1
6 · The paper itself

Abstract

Fibrillin‑1 (FBN1) mutations lead to extracellular matrix (ECM) defects with progressive aortic dilation in Marfan's syndrome (MFS). MFS thoracic aortas have increased stiffness, but how visco-elastic and microstructural abnormalities affect in vivo hemodynamics remains inconclusive. We applied ex vivo uniaxial visco-elasticity stress-relaxation testing and simultaneous 3D collagen Second Harmonic Generation (SHG) imaging to MFS and wt littermate linearized aortic strips with in vivo vascular function. MFS mouse (Fbn1

Indexed as

aneurysmaortabiomechanicsMarfan syndromeMechaMorphmgR/mgR micepulse wave velocity (PWV)Second Harmonic Generationvisco‐elasticity

Identifiers

PMID42702804
PMCPMC13547705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.