Evidence map›Paper›PMID 42702761›Full record

ArticleCancer medicine2026

Single-Cell Transcriptome of Anaplastic Thyroid Cancer Reveals Immunosuppressive Tumor Microenvironment Remodeling.

Saeko Tahara, Akiko Iguchi-Manaka, Naoto Takeuchi, Tomohei Matsuo, Akira Shibuya, Kazuko Shibuya, Haruka Ozaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saeko TaharaBioinformatics Laboratory, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0001-6343-2589
Akiko Iguchi-ManakaDepartment of Breast and Endocrine Surgery, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-0338-130X
Naoto TakeuchiDepartment of Immunology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Tomohei MatsuoDepartment of Breast-Thyroid-Endocrine Surgery, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0001-5630-5100
Akira ShibuyaDepartment of Immunology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-4480-4858
Kazuko ShibuyaDepartment of Immunology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-8203-2342
Haruka OzakiBioinformatics Laboratory, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-1606-2762

Funding

Japan Society for the Promotion of Science JP20K08950
6 · The paper itself

Abstract

Anaplastic thyroid cancer (ATC) is a rare but extremely aggressive malignancy responsible for most thyroid cancer-related deaths. To elucidate molecular and immunological characteristics distinguishing ATC from aggressive papillary thyroid cancer (PTC), we performed single-cell RNA sequencing on three ATC and three lethal PTC samples. ATC tumor cells exhibited enhanced inflammatory and immune-related gene expression, and co-activation of MAPK and PI3K pathways. Notably, p53 pathway activity was suppressed in ATC, alongside activation of angiogenic and immune-evasion programs, indicating a shift from proliferation-driven to immune-evasion-oriented signaling. Transcriptional network analysis revealed E2F family activation, including E2F1, E2F7, and E2F8, suggesting CDK-RB-E2F axis dysregulation drives tumor dedifferentiation and proliferation, whereby p53 suppression unleashes E2F-dependent transcriptional reprogramming. Immunoprofiling revealed CD8

Indexed as

Thyroid Carcinoma, AnaplasticThyroid NeoplasmsTranscriptomeTumor MicroenvironmentGene Expression Regulation, NeoplasticHumansSignal TransductionSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisThyroid Cancer, PapillaryT-Lymphocytes, RegulatoryTumor Suppressor Protein p53Tumor Suppressor Protein p53anaplastic thyroid cancercancer associated fibroblastE2Fimmune checkpoint moleculesMAPK signalingP53 pathwaypapillary thyroid cancerregulatory T cellsingle cell transcriptomicstumor microenvironment

Identifiers

PMID42702761
PMCPMC13547591

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.