Evidence map›Paper›PMID 42702703›Full record

ReviewMolecular neurobiology2026

Eugenol as a Potential Neuroprotective Agent in Neuroinflammation Models: a Mini-Review.

Sungmoo Hong, Kyungsook Jung, Taeyoung Kang, Hyohoon Jeong, Meejung Ahn, Changjong Moon, Hiroshi Matsuda, Akane Tanaka, Kazuhiro Yamamoto, Yoshihiro Nomura and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sungmoo Hong *College of Veterinary Medicine, Veterinary Medical Research Institute, Jeju National University, Jeju, 63243, Republic of Korea.
Kyungsook Jung *Functional Biomaterials Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, 56212, Republic of Korea.
Taeyoung KangCollege of Veterinary Medicine, Veterinary Medical Research Institute, Jeju National University, Jeju, 63243, Republic of Korea.
Hyohoon JeongCollege of Veterinary Medicine, Veterinary Medical Research Institute, Jeju National University, Jeju, 63243, Republic of Korea.
Meejung AhnDepartment of Anatomy and Cell Biology, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Changjong MoonDepartment of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju, 61186, Republic of Korea.
Hiroshi MatsudaLaboratory of Comparative Animal Medicine, Division of Animal Life Science, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-Shi, Tokyo, 183-8509, Japan.
Akane TanakaLaboratory of Comparative Animal Medicine, Division of Animal Life Science, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-Shi, Tokyo, 183-8509, Japan.
Kazuhiro YamamotoScleroprotein and Leather Research Institute, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-Shi, Tokyo, 183-8509, Japan.
Yoshihiro NomuraScleroprotein and Leather Research Institute, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-Shi, Tokyo, 183-8509, Japan.
Myung-Bok WieCollege of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, 24341, Republic of Korea. mbwie@kangwon.ac.kr.
Jeongtae KimScleroprotein and Leather Research Institute, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-Shi, Tokyo, 183-8509, Japan. kimjt78@jejunu.ac.kr.
Taekyun ShinCollege of Veterinary Medicine, Veterinary Medical Research Institute, Jeju National University, Jeju, 63243, Republic of Korea. shint@jejunu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eugenol is a naturally occurring volatile phenolic compound derived primarily from cloves; it exhibits diverse biological activities, including local anesthetic, antioxidant, anti-inflammatory, antimicrobial, and preservative effects, supporting its use as an oral disinfectant. Notably, eugenol mitigates oxidative stress, a key contributor to disease progression and aging; furthermore, eugenol exerts anti-inflammatory effects by inhibiting multiple proinflammatory mediators, reducing tissue damage. Our review provides new insights into the antioxidant and anti-inflammatory properties of eugenol and its underlying mechanisms in various models of neuroinflammation. Based on the literature, eugenol represents a promising candidate for mitigating neuroinflammatory processes, likely through its combined antioxidant, anti-inflammatory, and neuroprotective activities.

Indexed as

EugenolInflammationNeuroinflammatory DiseasesNeuroprotective AgentsAnimalsAnti-Inflammatory AgentsAntioxidantsDisease Models, AnimalHumansOxidative StressAnti-Inflammatory AgentsAntioxidantsEugenolNeuroprotective AgentsAnti-inflammationEugenolExperimental autoimmune encephalomyelitisNeuroinflammationNeuroprotection

Identifiers

PMID42702703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.