Evidence map›Paper›PMID 42702643›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Association between p-tau181 in cerebrospinal fluid and shunt response in patients with normal-pressure hydrocephalus.

Amon Bergner, Christian Sandøe Musaeus, Anja Hviid Simonsen, Tina Nørgaard Munch, Jonathan Frederik Carlsen, Steen Gregers Hasselbalch

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Amon BergnerDanish Dementia Research Centre, Section 8008, Department of Neurology, Copenhagen University Hospital, Inge Lehmanns Vej 8, DK-2100, Copenhagen, Rigshospitalet, Denmark. amon.bergner.01@regionh.dk.ORCID http://orcid.org/0000-0002-1706-8568
Christian Sandøe MusaeusDanish Dementia Research Centre, Section 8008, Department of Neurology, Copenhagen University Hospital, Inge Lehmanns Vej 8, DK-2100, Copenhagen, Rigshospitalet, Denmark.ORCID http://orcid.org/0000-0002-6442-2910
Anja Hviid SimonsenDanish Dementia Research Centre, Section 8008, Department of Neurology, Copenhagen University Hospital, Inge Lehmanns Vej 8, DK-2100, Copenhagen, Rigshospitalet, Denmark.ORCID http://orcid.org/0000-0002-5461-162X
Tina Nørgaard MunchDepartment of Clinical Medicine, Faculty of Health and Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5938-000X
Jonathan Frederik CarlsenDepartment of Clinical Medicine, Faculty of Health and Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6724-7281
Steen Gregers HasselbalchDanish Dementia Research Centre, Section 8008, Department of Neurology, Copenhagen University Hospital, Inge Lehmanns Vej 8, DK-2100, Copenhagen, Rigshospitalet, Denmark.ORCID http://orcid.org/0000-0003-4750-4911

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdiopathic normal pressure hydrocephalus (iNPH) is a treatable condition, but predicting shunt response remains challenging. Cerebrospinal fluid (CSF) biomarkers, including phosphorylated tau (p-tau181), have been suggested as potential predictors, although existing evidence is inconsistent.

methodsIn this retrospective single-center study, we included 230 patients with probable or possible iNPH who underwent shunt surgery and had available CSF biomarker data for Amyloid beta42, total tau and phosphorylated tau 181. Patients were divided into two cohorts based on assay method (Innotest

resultsMean CSF p-tau181 levels did not differ significantly between responders and non-responders in either cohort. In multivariable logistic regression analyses adjusted for age and sex, CSF p-tau181 was not associated with shunt response (Innotest

conclusionCSF p-tau181 does not demonstrate clinically meaningful predictive value for shunt response in patients with iNPH and cannot alone guide patient selection for shunt surgery. Future research should focus on multimodal approaches integrating clinical, radiological, and biochemical markers.

Indexed as

Cerebrospinal Fluid ShuntsHydrocephalus, Normal Pressuretau ProteinsAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersFemaleHumansMalePeptide FragmentsPhosphorylationRetrospective StudiesTreatment OutcomeAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersMAPT protein, humanPeptide Fragmentstau ProteinsCerebrospinal fluidNormal-pressure hydrocephalusP-tau181Shunt response

Identifiers

PMID42702643
PMCPMC13547186

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.