Evidence map›Paper›PMID 42702622›Full record

ArticleNature communications2026

A functional atlas of transposon-encoded products and their integration into host networks.

Carles Borredá, Pol Vendrell-Mir, Basile Leduque, Mireia Bueno Merino, Céline Oury, Nathalie Glab, Vincent Colot, Leandro Quadrana

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carles BorredáInstitute of Plant Sciences Paris-Saclay (IPS2), Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAe), Université Evry, Université Paris Diderot, Gif sur Yvette, France.ORCID http://orcid.org/0000-0001-9624-7152
Pol Vendrell-MirInstitute of Plant Sciences Paris-Saclay (IPS2), Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAe), Université Evry, Université Paris Diderot, Gif sur Yvette, France.
Basile LeduqueInstitute of Plant Sciences Paris-Saclay (IPS2), Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAe), Université Evry, Université Paris Diderot, Gif sur Yvette, France.ORCID http://orcid.org/0000-0002-9450-3586
Mireia Bueno MerinoInstitute of Plant Sciences Paris-Saclay (IPS2), Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAe), Université Evry, Université Paris Diderot, Gif sur Yvette, France.
Céline OuryInstitute of Plant Sciences Paris-Saclay (IPS2), Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAe), Université Evry, Université Paris Diderot, Gif sur Yvette, France.
Nathalie GlabInstitute of Plant Sciences Paris-Saclay (IPS2), Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAe), Université Evry, Université Paris Diderot, Gif sur Yvette, France.
Vincent ColotInstitut de Biologie de l'Ecole Normale Supérieure (IBENS), Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), École Normale Supérieure, PSL Research University, Paris, France.ORCID http://orcid.org/0000-0002-6382-1610
Leandro QuadranaInstitute of Plant Sciences Paris-Saclay (IPS2), Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAe), Université Evry, Université Paris Diderot, Gif sur Yvette, France. leandro.quadrana@cnrs.fr.ORCID http://orcid.org/0000-0001-6279-211X

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 948674
6 · The paper itself

Abstract

Transposable elements (TEs) are pervasive genomic components that propagate via self-encoded factors, yet the nature, regulation, and function of these factors remain largely unresolved. Here, we integrated extensive long- and short-read transcriptome data, regulatory network analyses, deep proteomics, and structural predictions to construct a comprehensive atlas of TE products in Arabidopsis. We show that TE expression is embedded within host regulatory circuits, with DNA methylation and transcription factors jointly shaping TE transcriptional activity. Proteomic analyses confirm the production of over a hundred of high-confidence TE-encoded proteins, and structure-guided analyses of the transcript-informed TE proteome predict previously uncharacterized structural folds, multimerization capacity, and host protein interaction potential. Structural alignments further uncover cryptic homologies between TE-encoded proteins and host factors, including cases of domestications and co-options. Together, our study reveals the functional integration of TEs into cellular pathways and underscores the role of TEs as active drivers of genome function and innovation.

Indexed as

ArabidopsisArabidopsis ProteinsDNA Transposable ElementsGene Regulatory NetworksDNA MethylationGene Expression Regulation, PlantProteomeProteomicsTranscription FactorsTranscriptomeArabidopsis ProteinsDNA Transposable ElementsProteomeTranscription Factors

Identifiers

PMID42702622
PMCPMC13547354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.