ArticleNature communications2026
Synthetic cargo adaptors reveal molecular features that enhance dynein activation.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Activating adaptor-like sequences in pericentrin mediate its transport by dynein.bioRxiv : the preprint server for biology · 2026Article
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11 authors.
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Abstract
Cytoplasmic dynein-1 (dynein) facilitates the microtubule-based retrograde trafficking of all cellular cargo. To become active, dynein binds dynactin and one of many cargo-specific adaptors forming the dynein-dynactin-adaptor transport complex. Despite having similar structures, transport complexes assembled with different adaptors move with different properties in vitro. To explore how adaptors activate dynein, we engineered a library of synthetic adaptors and characterized their ability to activate dynein using in vitro reconstitution and cell-based trafficking assays. We found that dynein motility is highly plastic and tunable by the adaptor, and that it is possible to engineer adaptors that outperform endogenous adaptors' ability to generate highly motile transport complexes. We also found that different adaptors support distinct cellular trafficking behavior and cargo movement. In this study, we provide insight into how dynein motility is modulated to meet the unique trafficking requirements of all cellular cargo.
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