Evidence map›Paper›PMID 42702401›Full record

ReviewPhytotherapy research : PTR2026

Pharmacokinetic and Pharmacodynamic Interactions Between Anti-Asthma Drugs and Medicinal Plants: A Comprehensive Review.

Emine Kocyigit, Aylin Bülbül, Betul Kocaadam-Bozkurt, Osman Bozkurt, Duygu Ağagündüz, Raffaele Capasso

Abstract readReview
In one paragraph

Review in Phytotherapy research : PTR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emine KocyigitDepartment of Nutrition and Dietetics, Ordu University, Ordu, Türkiye.ORCID https://orcid.org/0000-0002-9459-9557
Aylin BülbülDepartment of Nutrition and Dietetics, Ordu University, Ordu, Türkiye.ORCID https://orcid.org/0000-0002-4754-0149
Betul Kocaadam-BozkurtDepartment of Nutrition and Dietetics, Erzurum Technical University, Erzurum, Türkiye.ORCID https://orcid.org/0000-0002-9058-4630
Osman BozkurtDepartment of Nutrition and Dietetics, Kulu Faculty of Health Sciences, Konya, Türkiye.ORCID https://orcid.org/0000-0002-5829-7543
Duygu AğagündüzDepartment of Nutrition and Dietetics, Gazi University, Ankara, Türkiye.ORCID https://orcid.org/0000-0003-0010-0012
Raffaele CapassoDepartment of Agricultural Sciences, University of Naples Federico II, Portici, Italy.ORCID https://orcid.org/0000-0002-3335-1822

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma affects 260-300 million people worldwide. About 20%-35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts. Previous reviews discussed herb-drug interactions and asthma phytotherapy separately. There is no combined pharmacokinetic, pharmacodynamic, and toxicological evidence for all modern anti-asthma agents. This review closes that gap. It draws from mechanistic, preclinical, and clinical data. It looks at eight common botanicals: Glycyrrhiza glabra , Curcuma longa , Nigella sativa , Boswellia serrata , Tylophora indica, Adhatoda vasica , Astragalus membranaceus, and Piper nigrum. The review explains how these botanicals affect cytochrome P450 isoenzymes, Phase II conjugative enzymes, and membrane transporters, including P-glycoprotein. It also considers shared adrenergic, glucocorticoid-receptor, and inflammatory targets of inhaled corticosteroids, β

Indexed as

Anti-Asthmatic AgentsAsthmaHerb-Drug InteractionsPlants, MedicinalAnimalsCytochrome P-450 Enzyme SystemHumansPhytotherapyPlant ExtractsAnti-Asthmatic AgentsCytochrome P-450 Enzyme SystemPlant Extractsasthmacomplementary medicineherb–drug interactionsmedicinal plantspharmacodynamicspharmacokineticstoxicity

Identifiers

PMID42702401
PMCPMC13753711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.