ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
Life
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Association of wearableZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
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Authors and funding
13 authors.
Funding
Abstract
objectivesMaintaining brain health while extending life expectancy is an important public health challenge in aging societies. However, the association between cardiovascular health (CVH) and brain health has not been fully established. This study aims to develop a Life's Essential 10 (LE10) framework for assessing CVH and to evaluate the effects of different CVH levels on life expectancy free of stroke and dementia.
methodsThis prospective cohort study included adults aged 37-73 years from the UK Biobank who had no history of stroke or dementia at baseline and had complete data on LE10 metrics and covariates. The LE10 framework developed in this study was based on Life's Essential 8 (LE8), which comprises eight domains, diet, physical activity, nicotine exposure, sleep duration, body mass index, blood lipids, blood pressure, and blood glucose, and additionally incorporated alcohol consumption and sedentary behavior. A total score was calculated by assigning a score to each domain, and participants were categorized as having low, moderate, or high CVH. The primary outcome was life expectancy free of stroke and dementia. Secondary outcomes included the risk of the composite endpoint of stroke or dementia, the risk of all-cause mortality, and total life expectancy.
resultsAmong 122 953 participants, with a mean age of 55.7 years and 48.4% being women, 13.2%, 60.0%, and 26.8% had low, moderate, and high CVH, respectively. During a median follow-up of 13.8 years, 4 776 composite endpoint events, 3 317 cases of stroke, 1 697 cases of dementia, and 7 825 deaths were recorded. Compared with low CVH, high CVH was associated with a lower risk of the composite endpoint in both men (
conclusionsHigher CVH, as assessed using the LE10 framework, was closely associated with better preservation of brain health and a lower risk of all-cause mortality. Improving the CVH-related behaviors and metabolic factors included in LE10 may contribute to greater longevity and the maintenance of brain health.
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