ArticleClinics (Sao Paulo, Brazil)2026
Chemotherapy is associated with faster abdominal aortic aneurysm growth in patients with concomitant cancer in a multicenter cohort.
Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the prevalence of synchronous Abdominal Aortic Aneurysm (AAA) and malignancy and the impact of different cancer treatments on the natural history of aortic aneurysms, focusing on its growth and risk of rupture.
designRetrospective multicenter observational study.
methodsImaging scans were examined to select patients with abdominal aortic aneurysms. Aortic diameters, aortic rupture, demographic and clinical data from patients with abdominal aortic aneurysms with or without cancer (controls) treated at four medical centers in Brazil were retrospectively analyzed.
results27,455 abdominal scans were screened, resulting in 297 patients with AAA being included. Of these patients, 220 had concomitant cancer. The prevalence of AAA and cancer was 2.4%. A further 73 patients with AAA but no cancer were recruited from an outpatient cohort to also join the control group of 77 patients, resulting in 150. No aortic rupture was observed. In multivariable analysis, larger baseline aortic diameter (p < 0.001) and exposure to alkylating agents (p = 0.023), antimetabolites (p = 0.023), and topoisomerase inhibitors (p = 0.003) were independently associated with increased AAA growth rates. Neither cancer diagnosis nor radiotherapy exposure was significantly associated with AAA growth.
conclusions2.4% of cancer patients had a concomitant AAA. Aneurysm growth rates were significantly influenced by the initial aortic diameter and by treatment with three classes of chemotherapy drugs: alkylating agents, antimetabolites and topoisomerase inhibitors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.