Evidence map›Paper›PMID 42701962›Full record

ArticleJournal of molecular histology2026

The neuroprotective potential of thymoquinone and intermittent fasting on aluminum chloride-induced Alzheimer's disease like model in rat hippocampus: insights into neurogenesis and autophagy.

Reem Ahmed Abd El-Salam, Azza Radwan El-Hadidy, Nesreen Moustafa Omar, Nahla Reda Sarhan

Abstract read
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Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Reem Ahmed Abd El-SalamDepartment of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.ORCID http://orcid.org/0000-0003-3702-3460
Azza Radwan El-HadidyDepartment of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Nesreen Moustafa OmarDepartment of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.ORCID http://orcid.org/0000-0001-7483-4030
Nahla Reda SarhanDepartment of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt. nahlaredasarhan@mans.edu.eg.ORCID http://orcid.org/0000-0001-6332-2398

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Thymoquinone (TQ) is the active component of black seeds with many health benefits. Intermittent fasting (IF) is a dietary pattern with antioxidant and neuro-regenerative effects. This study explored the neuroprotective potential of TQ, IF or their combination on hippocampus of AD-like rat model with emphasis on the underlying mechanisms as neurogenesis and autophagy. Eighty adult male rats were divided into 7 groups: control, TQ given TQ (50 mg/kg/day orally), IF underwent IF for 14 h/day, AL given Aluminum chloride (AlCl

Indexed as

Alzheimer DiseaseAutophagyBenzoquinonesHippocampusIntermittent FastingNeurogenesisNeuroprotective AgentsAluminum ChlorideAnimalsApoptosisDisease Models, AnimalMaleOxidative StressRatsAluminum ChlorideBenzoquinonesNeuroprotective AgentsthymoquinoneAlzheimer’s diseaseAutophagyIntermittent fastingNeurogenesisThymoquinone

Identifiers

PMID42701962

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.