Evidence map›Paper›PMID 42701961›Full record

ArticlePediatric surgery international2026

The clinical characteristics and prognostic factors of neonatal gastric perforation and rupture: a multicenter retrospective study in Japan.

Toshio Harumatsu, Koshiro Sugita, Ayano Hidaka, Tsubasa Goshima, Shohei Yoshimura, Daisuke Masui, Tokuro Baba, Hirofumi Tomita, Naoki Shimojima, Tadashi Hatakeyama and 3 more

Abstract readMulticenter Study
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In one paragraph

Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Toshio HarumatsuDepartment of Pediatric Surgery, Kagoshima City Hospital, Kagoshima, Japan.
Koshiro SugitaDepartment of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, Kagoshima, Japan.
Ayano HidakaDepartment of Surgery, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Tsubasa GoshimaDivision of Surgery, Department of Surgical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.
Shohei YoshimuraDepartment of Pediatric Surgery, Hyogo Prefectural Kobe Children's Hospital, Kobe, Hyogo, Japan.
Daisuke MasuiDepartment of Pediatric Surgery, Division of Surgery, Kurume University School of Medicine, Fukuoka, Japan.
Tokuro BabaDepartment of Digestive and Oncological Surgery, University of the Ryukyus Hospital, Ginowan, Okinawa, Japan.
Hirofumi TomitaDepartment of Surgery, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Naoki ShimojimaDivision of Surgery, Department of Surgical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.
Tadashi HatakeyamaDepartment of Pediatric Surgery, Hyogo Prefectural Kobe Children's Hospital, Kobe, Hyogo, Japan.
Motofumi TorikaiDepartment of Pediatric Surgery, Kagoshima City Hospital, Kagoshima, Japan.
Tatsuru KajiDepartment of Pediatric Surgery, Division of Surgery, Kurume University School of Medicine, Fukuoka, Japan.
Satoshi IeiriDepartment of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, Kagoshima, Japan. sieiri@m.kufm.kagoshima-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNeonatal gastric perforation is a life-threatening surgical emergency with high mortality rates. The confounding effect of tracheoesophageal fistula (TEF) on prognostic analyses remains inadequately addressed. This study aimed to identify the prognostic factors for in-hospital mortality using a multicenter analysis.

methodsWe conducted a retrospective study at six tertiary pediatric surgery centers in Japan, including all neonates who underwent surgical treatment for either gastric perforation or rupture between 1994 and 2025. Logistic regression and sensitivity analyses, excluding TEF cases, were performed.

resultsThirty-seven patients were identified, with a median birth weight of 1202 g, of whom 56.8% had a very low birth weight. The overall mortality rate was 37.8% (14/37). On a multivariate analysis, TEF was the strongest independent prognostic factor (OR 51.85, 95% CI 3.26-824.6; p = 0.005). In the sensitivity analysis excluding TEF cases (n = 28), the age at surgery (OR 1.23, 95% CI 1.01-1.51; p = 0.041) and the perforation length (OR 1.09, 95% CI 1.00-1.18; p = 0.043) were significant predictors of mortality.

conclusionTEF is the strongest prognostic factor for neonatal gastric perforation. Excluding TEF confounding factors revealed the prognostic importance of the age at surgery and the perforation size, highlighting the value of early diagnosis and management.

Indexed as

Stomach RuptureFemaleHospital MortalityHumansInfant, NewbornJapanMalePrognosisRetrospective StudiesRupture, SpontaneousIn-hospital mortalityMulticenter studyNeonatal gastric perforationPrognostic factorsTracheoesophageal fistula

Identifiers

PMID42701961

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