ArticlePeerJ2026
Adipose tissue metabolic dysregulation in diet-induced obesity: insights from UHPLC-HRMS-based metabolomics.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Obesity and related metabolic complications are associated with adipose tissue (AT) dysfunction, which contributes to metabolic inflexibility. However, the underlying mechanisms remain unclear. Our previous studies demonstrated that a high-fat diet (HFD) induces weight gain, increased fat weight, as well as significant metabolite alterations in serum, liver, and cecum in mice. Therefore, this study aims to investigate the effect of HFD on AT metabolites to elucidate their role in obesity progression. Methods: To establish a diet-induced obesity model, nine female Kunming mice were fed a high-fat diet (HFD) for 16 weeks and compared with nine control mice maintained on a normal diet. Subcutaneous abdominal adipose tissue samples (SAAT) were analyzed using ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) coupled with orthogonal partial least squares discriminant analysis (OPLS-DA). Results: By metabolic profiling, 48 significantly different metabolites were identified, including phosphatidylcholines (PCs), lysophosphatidylcholines (LysoPCs), Conclusions: These identified metabolites in SAAT may aid in understanding of the mechanism by which HFD promotes the progression of obesity and related diseases.
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