Evidence map›Paper›PMID 42701733›Full record

ArticleBioinformation2026

Comparative analysis on the effect of vagus nerve stimulation in reducing post-operative inflammation and enhancing recovery outcomes after surgery.

Richa Kumari, Gaurav Gupta, Sangeeta Gupta, Parth Jani

Abstract read
In one paragraph

Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Richa KumariDepartment of Physiology, Maharishi Vashishth Autonomous State Medical College, Basti, Uttar Pradesh, India.
Gaurav GuptaDepartment of General Surgery, AIIMS Gorakhpur, Uttar Pradesh, India.
Sangeeta GuptaDepartment of Physiology, AIIMS Gorakhpur, Uttar Pradesh, India.
Parth JaniDepartment of General Medicine, Government Medical College, Bhavnagar, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive post-operative inflammation remains a major cause of complications, delayed recovery and prolonged hospitalization after major surgery. Therefore, it is of interest to evaluate the effect of perioperative transcutaneous auricular vagus nerve stimulation (taVNS) on inflammatory biomarkers and recovery outcomes in 90 patients undergoing elective abdominal and cardiothoracic surgery. Patients receiving taVNS demonstrated significantly lower IL-6, TNF-α and CRP levels, together with higher IL-10 concentrations, than those receiving standard care. The taVNS group also showed earlier ambulation, lower pain scores, reduced analgesic requirements and shorter hospital stays. Thus, data shows the taVNS as a safe, non-invasive neuromodulatory strategy that effectively suppresses post-operative inflammation while accelerating clinical recovery.

Indexed as

cholinergic anti-inflammatory pathwaycytokinesperioperative neuromodulationpost-operative inflammationsurgical recoverytranscutaneous auricular VNS (taVNS)Vagus nerve stimulation (VNS)

Identifiers

PMID42701733
PMCPMC13545867

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.