Evidence map›Paper›PMID 42701697›Full record

ArticleBioinformation2026

Salivary cathelicidin LL-37 as a non-invasive biomarker for oral cancer detection.

Thaneja Ravichandran, Harshavardhan B G, Nandhini Ganesan, Sarswathi Gopal K

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Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Thaneja RavichandranDepartment of Oral Medicine and Radiology, Meenakshi Ammal Dental College and Hospital, Meenakshi academy of higher education and research, Chennai, Tamil Nadu, India.
Harshavardhan B GDepartment of Oral Medicine and Radiology, Meenakshi Ammal Dental College and Hospital, Meenakshi academy of higher education and research, Chennai, Tamil Nadu, India.
Nandhini GanesanDepartment of Oral Medicine and Radiology, Meenakshi Ammal Dental College and Hospital, Meenakshi academy of higher education and research, Chennai, Tamil Nadu, India.
Sarswathi Gopal KDepartment of Oral Medicine and Radiology, Meenakshi Ammal Dental College and Hospital, Meenakshi academy of higher education and research, Chennai, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is the predominant form of oral malignancy, with late-stage diagnosis contributing to poor prognosis. Oral potentially malignant disorders (OPMDs) often precede OSCC, underscoring the need for early diagnostic biomarkers. Hence, salivary cathelicidin LL-37 levels were quantified using ELISA in 80 participants. Participants were divided into four groups: OSCC, tobacco- associated OPMDs, non-tobacco-associated OPMDs, and healthy controls. Salivary cathelicidin LL-37 levels increased progressively from healthy controls to OSCC cases (p < 0.001) with 100% sensitivity and 90% specificity. Thus, we show that salivary LL-37 is a reliable, non-invasive biomarker for early detection and monitoring of oral carcinogenesis.

Indexed as

Biomarkeroral malignancyoral potentially malignant disorder (OPMD)oral squamous cell carcinoma (OSCC)

Identifiers

PMID42701697
PMCPMC13545870

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.