Evidence map›Paper›PMID 42701677›Full record

ArticleStructural heart : the journal of the Heart Team2026

Sex-Specific Differences in Clinical Outcomes After Transcatheter Aortic Valve Replacement: A Meta-Analysis of Reconstructed Individual Patient Survival Data.

Ali M Abdelaziz, Mohamedhen Vall Nounou, Ahmad Al Othman, Mirvat Alasnag, Alaide Chieffo, J Dawn Abbott, Abubaker Al-Allawee, Sofian Zreigh, Mohammed Benhammou, Muhiddin Dervis and 11 more

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Article in Structural heart : the journal of the Heart Team, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ali M AbdelazizFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Mohamedhen Vall NounouFaculty of Medicine, University of Nouakchott Al Aasrya, Nouakchott, Mauritania.
Ahmad Al OthmanDepartment of Medicine, Faculty of Medicine, Near East University, Nicosia, Cyprus.
Mirvat AlasnagCardiac Center, King Fahd Armed Forces Center, Jeddah, Saudi Arabia.
Alaide ChieffoCardiology Department, Vita Salute San Raffaele University, Milan, Italy.
J Dawn AbbottDepartment of Medicine, Division of Cardiology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Abubaker Al-AllaweeCollege of Medicine, University of Fallujah, Fallujah, Iraq.
Sofian ZreighFaculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey.
Mohammed BenhammouFaculty of Medicine, University of Oran 1, Oran, Algeria.
Muhiddin DervisFaculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey.
Walid GuerguerFaculty of Medicine, University of Health Sciences, Algiers, Algeria.
Ashraf HaidarahWest China Hospital, Sichuan University, Chengdu, Sichuan, China.
Rafeek ElmezayenFaculty of Medicine, Kafr El-Sheikh University, Kafr El-Sheikh, Egypt.
Mohammad Alzu'biFaculty of Medicine, The Hashemite University, Zarqa, Jordan.
Serag AlmzainyFaculty of Medicine, University of Tripoli, Tripoli, Libya.
Saber KhalidFaculty of Medicine, University of Benghazi, Benghazi, Libya.
Qasim ShaweshDepartment of Internal Medicine, HCA Mountain View Hospital, Las Vegas, Nevada, USA.
Maram AbuajamiehFaculty of Medicine, Cairo University, Cairo, Egypt.
Muhammed ElhadiFaculty of Medicine, University of Tripoli, Tripoli, Libya.
Rodrigo BagurDepartment of Medicine, London Health Sciences Centre, Western University, London, Ontario, Canada.
Mamas A MamasKeele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, Keele, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Females with severe aortic stenosis present with distinct anatomical and clinical characteristics compared to males, which may influence outcomes following transcatheter aortic valve replacement (TAVR). We sought to investigate the prognostic impact of sex-specific differences on short- and long-term outcomes following TAVR. Methods: PubMed, Embase, Scopus, and Web of Science were searched through August 2025 for randomized and observational studies reporting sex-specific outcomes after TAVR. Reconstructed individual patient data from published Kaplan-Meier (KM) curves were used to estimate long-term survival outcomes. Results: Overall, 71 studies involving 481,353 patients were included. Compared with males, females demonstrated a higher short-term risk of adverse outcomes, including 30-day all-cause mortality (hazard ratio [HR]: 1.064, 95% CI: 1.005-1.127; Conclusions: Females undergoing TAVR experience higher early risks of mortality, stroke, bleeding, and vascular complications, but exhibit a sustained long-term survival advantage compared with males, highlighting the need for sex-centered periprocedural management strategies.

Indexed as

Aortic stenosisCardiovascular disease in womenSex differencesTAVITAVR

Identifiers

PMID42701677
PMCPMC13545726

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