ArticleCureus2026
Age-Related Time-to-Onset Analysis of Drug-Associated Erythema Multiforme Using the Japanese Adverse Drug Event Report Database.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionErythema multiforme (EM) is a rare immune-mediated skin condition often triggered by infections, drugs, or autoimmune diseases. Age-related differences in drug exposure, comorbidities, and biological factors may affect adverse event reporting patterns; however, age-related patterns in EM onset remain unclear. This study investigated age-related patterns in reported time-to-onset of EM.
methodsThe observation period was defined as 1-180 days from the initiation of drug administration. Kendall's tau-b rank correlation analysis was used to evaluate the association between ordered age categories and reported time to onset. The Kaplan-Meier method with a log-rank test was used to compare EM onset profiles between two age groups (<60 and ≥60 years).
resultsA positive association was observed between age category and reported time-to-onset (Kendall's tau-b = 0.188, p < 0.001). The median time-to-onset was 10.0 days in both men and women, although the Kaplan-Meier curves differed significantly by sex (log-rank p = 0.012). The median time-to-onset was 8.0 (3.0-13.0) days for those aged <60 years and 12.0 (7.0-24.5) days for those aged ≥60 years (log-rank p < 0.001).
conclusionsOlder age was associated with longer reported time-to-onset of EM, suggesting age-related differences in reported EM onset patterns in a spontaneous reporting database.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.