Comparative analysis of EGFR expression in tobacco-related and HPV-associated oral cancer.

Lavanya R M, Megha Modi, Devashree Shukla, Nandini C, Tamoghna Biswas, Arvind Jain

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Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Lavanya R MDepartment of Oral Pathology, Rajiv Gandhi Dental College, Bengaluru, Karnataka, India.

Megha ModiDepartment of Oral and Maxillofacial Surgery, New York University College of Dentistry, New York, United States.

Devashree ShuklaDepartment of Dentistry, LN medical College and JK Hospital, Kolar Road, Bhopal, Madhya Pradesh, India.

Nandini CDepartment of Oral Pathology, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India.

Tamoghna BiswasDepartment of Oral Medicine and Radiology, Saraswati Dental College, Atal Bihari Vajpayee University, Lucknow, Uttar Pradesh, India.

Arvind JainDepartment of Oral Pathology and Microbiology, Maitri College of Dentistry and Research Centre, Durg, Chhattisgarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Differences in epidermal growth factor receptor (EGFR) expression between tobacco-related and human papillomavirus (HPV)-associated oral squamous cell carcinoma (OSCC) remain insufficiently defined. Therefore, it is of interest to compare EGFR expression in 90 histopathologically confirmed OSCC cases, including tobacco-related OSCC and HPV-associated OSCC. Immunohistochemistry (IHC) was used to assess EGFR expression, while p16 immunostaining served as a surrogate marker for HPV status. Tobacco-related OSCC demonstrated higher EGFR expression than HPV-associated OSCC, indicating differences in tumor biology and therapeutic response. Thus, we show etiological variation in EGFR expression in OSCC, supporting development of targeted and personalized treatment strategies.

Indexed as

Epidermal growth factor receptor (EGFR) expressionoral cancer HPV-associationoral squamous cell carcintobacco

Identifiers

PMID42701634

DOI10.6026/973206300223310

PMCPMC13545962

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.