ArticleQuantitative imaging in medicine and surgery2026
Preoperative assessment of recurrence-prone subregions within the peritumoral region of glioblastoma: a comparison between diffusion kurtosis and diffusion tensor imaging.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Glioblastoma (Gb) is characterized by extensive infiltration beyond the contrast-enhancing tumor margin, and most recurrences occur within the peritumoral region. Preoperative identification of recurrence-prone subregions within the peritumoral area may help optimize local treatment strategies. Diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) can provide quantitative information on tissue microstructure, but their value in distinguishing recurrence-prone and non-recurrent subregions within the peritumoral region of Gb remains unclear. This study aimed to evaluate and compare the value of preoperative DKI- and DTI-derived histogram parameters in distinguishing recurrence-prone from non-recurrent subregions within the peritumoral region of Gb. Methods: This retrospective study included 55 patients with Gb who subsequently developed recurrence and underwent preoperative magnetic resonance imaging (MRI), including conventional sequences, DKI, and DTI. DKI data were processed to generate DKI- and DTI-derived parametric maps. All preoperative structural images and post-recurrence contrast-enhanced images were automatically coregistered to the preoperative diffusion parametric map space using ITK-SNAP. The edema region on preoperative fluid-attenuated inversion recovery (FLAIR) images and the contrast-enhancing lesion at first recurrence were initially segmented using an nnU-Net model and then jointly reviewed by two radiologists. The overlap between the preoperative FLAIR-hyperintense region and the contrast-enhancing lesion at first recurrence was defined as the recurrence-prone region, whereas the remaining FLAIR-hyperintense area was defined as the non-recurrent region. Histogram parameters were extracted from both regions. Differences in diffusion parameters were analyzed using paired-samples t-tests. P values for parameters showing significant differences were further adjusted using the Benjamini-Hochberg procedure. Receiver operating characteristic (ROC) analysis was performed, and the area under the curve (AUC) was calculated. Results: In the DKI model, maximum radial kurtosis (RK Conclusions: Preoperative DKI histogram analysis may help identify recurrence-prone subregions within the peritumoral region of Gb. In this cohort, the best-performing DKI-derived parameter showed the highest AUC compared with the best-performing DTI-derived parameter. These findings are exploratory and require validation in larger studies.
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