Evidence map›Paper›PMID 42701494›Full record

ArticleMolecular therapy. Oncology2026

Therapeutic targeting of cancer-associated fibroblasts with oncolytic virus in preclinical models of intrahepatic cholangiocarcinoma.

Aushinie Abeynayake, Timothy A Rengers, Danielle M Carlson, Amro M Abdelrahman, Justin W Maroun, Nidhi Jalan-Sakrikar, Velia Penza, Shruthi Naik, Mark J Truty, Caitlin B Conboy and 2 more

Abstract read
In one paragraph

Article in Molecular therapy. Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aushinie AbeynayakeDepartment of Surgery, Mayo Clinic, Rochester, MN, USA.
Timothy A RengersDepartment of Surgery, Duke University, Durham, NC, USA.
Danielle M CarlsonDepartment of Surgery, Mayo Clinic, Rochester, MN, USA.
Amro M AbdelrahmanDepartment of Surgery, Mayo Clinic, Rochester, MN, USA.
Justin W MarounDepartment of Surgery, Mayo Clinic, Rochester, MN, USA.
Nidhi Jalan-SakrikarDepartment of Gastroenterology, Mayo Clinic, Rochester, MN, USA.
Velia PenzaDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Shruthi NaikDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Mark J TrutyDepartment of Surgery, Mayo Clinic, Rochester, MN, USA.
Caitlin B ConboyDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.
Gregory J GoresDepartment of Gastroenterology, Mayo Clinic, Rochester, MN, USA.
Susanne G WarnerDepartment of Surgery, Mayo Clinic, Rochester, MN, USA.

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI GREGORY J. GORES · 2009 to 2026
$22.2M
Project 4: ImmunovirotherapyP50CA210964 · NCI · MAYO CLINIC ROCHESTER · PI Zongming Eric Chen · 2018 to 2026
$20.5M
Institutional Career Development CoreKL2TR002379 · NCATS · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2017 to 2026
$14.9M
NCATS NIH HHS KL2 TR002379NCI NIH HHS P50 CA210964NIDDK NIH HHS P30 DK084567
6 · The paper itself

Abstract

Intrahepatic cholangiocarcinoma (iCCA) is an aggressive malignancy with limited effective therapies. Treatment resistance is partly due to activated cancer-associated fibroblasts (CAFs), which induce pro-tumor signaling and formation of a highly fibrotic tumor microenvironment. CAFs exist on a functional spectrum of subtypes and are difficult to target

Indexed as

cancer-associated fibroblastsimmunotherapyintrahepatic cholangiocarcinomaoncolytic virusstromavaccinia virusvesicular stomatitis virusviroimmunotherapy

Identifiers

PMID42701494
PMCPMC13545436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.