ArticleQuantitative imaging in medicine and surgery2026
Effect of imaging parameters and clinical characteristics on pericoronary adipose tissue attenuation in patients without coronary plaque.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pericoronary adipose tissue (PCAT) attenuation serves as a marker of coronary inflammation. However, numerous confounders may affect PCAT attenuation. This study aimed to investigate the influence of coronary computed tomography angiography (CCTA) imaging parameters and clinical characteristics on the fat attenuation index (FAI) of PCAT. Methods: One hundred and ninety-six subjects [mean age ± standard deviation (SD), 55.4±9.5 years; 81 males] who underwent CCTA and had no coronary plaque were included in this retrospective study. Images were scanned at 100 or 120 kVp and reconstructed using two methods. PCAT attenuation was assessed using two measurement approaches: a proximal 40-mm segment of each coronary artery and a 10-mm segment in each coronary artery segment. The intraclass correlation coefficient (ICC) was used to assess interobserver agreement for FAI measurements. Linear regression analyses were performed to identify independent factors associated with FAI. Results: Interobserver agreement for FAI measurements was excellent, with an ICC of 0.985-0.998; 120 kVp was independently associated with higher FAI values across the majority of segments (β=4.9-8.1, all P<0.001), except for FAI Conclusions: In patients without coronary plaque, PCAT attenuation depends on imaging parameters and clinical characteristics, underscoring the importance of considering both imaging and clinical factors when interpreting FAI measurements.
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