ArticleCureus2026
Evaluation of Hematological Indices, Their Longitudinal Trends, and Association With Stratified Dengue Severity in Pediatric Cohorts: A Prospective Observational Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDengue fever is a widely prevalent viral disease, with one of the most common laboratory findings being thrombocytopenia. Although platelet indices like mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (P-LCR), and plateletcrit (PCT) are routinely measured, their utility in clinical practice has been limited. This study was planned to evaluate platelet indices across the range of disease severity, understand their importance in terms of their trends over the disease course, and correlate them with other hematological parameters in pediatric dengue.
methodsA prospective observational study was carried out on a sample of 55 children aged 0-18 years diagnosed with dengue fever in the inpatient pediatrics department. Data regarding clinical features, hematological parameters, including platelet indices, and other laboratory parameters over a period of three days were collected.
resultsA total of 27 (49%) study participants had dengue without warning signs (DF-1), 20 (36.3%) had dengue with warning signs (DF-2), and eight (14.5%) had severe dengue (DF-3). Significantly rising trends of MPV and PDW were observed in the DF-1 group, contrasting with a falling MPV and P-LCR among participants with severe dengue (DF-3). Moreover, PDW and P-LCR exhibited significant negative correlation with platelet count and PCT values, with MPV showing a significant but weak positive correlation with hematocrit.
conclusionMonitoring platelet index trends over the disease course, in conjunction with other parameters, can serve as an indirect indicator of the bone marrow response to thrombocytopenia. Falling trends of MPV, PDW, and P-LCR with low platelet counts could suggest a deteriorating patient course and may warrant more vigilant monitoring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.