Evidence map›Paper›PMID 42701421›Full record

Trial reportBJA open2026

A perioperative medicine platform trial (PROMPT) evaluating interventions to reduce the risk of infection and other major complications after surgery: rationale and design.

Paul S Myles, Trisha N Peel, Steve Webb, Sophie K Wallace, Wendy A Brown, Tomas Corcoran, Tracey Bucknall, Tim Coulson, Daniel Frei, Brett Mitchell and 5 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BJA open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07186634 (Domain-Specific Appendix), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07186634 phase4recruitingnot on this map

Domain-Specific Appendix: OXYGEN

TypeinterventionalSponsorMonash UniversityRan2026 to 2035Enrolled7,800ConditionsSurgical Site Infection After Major Surgery, Anaesthesia, Major Complications, Quality of Recovery (QoR-15)ArmsLiberal inspired oxygen, Conservative inspired oxygen, Intermediate inspired oxygen
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Paul S MylesDepartment of Anaesthesiology and Perioperative Medicine, Alfred Hospital and Monash University, Melbourne, Australia.
Trisha N PeelDepartment of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia.
Steve WebbSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Sophie K WallaceDepartment of Anaesthesiology and Perioperative Medicine, Alfred Hospital and Monash University, Melbourne, Australia.
Wendy A BrownDepartment of Surgery, Alfred Hospital and Monash University, Melbourne, Australia.
Tomas CorcoranDepartment of Anaesthesia and Pain Medicine, Royal Perth Hospital and the School of Emergency Medicine, University of Western Australia, Perth, Australia.
Tracey BucknallCentre for Quality and Patient Safety Research, Institute for Health Transformation, School of Nursing and Midwifery, Deakin University, Geelong, Australia.
Tim CoulsonDepartment of Anaesthesiology and Perioperative Medicine, Alfred Hospital and Monash University, Melbourne, Australia.
Daniel FreiDepartment of Anaesthesiology and Pain Management, Wellington Hospital and Medical Research Institute of New Zealand, New Zealand.
Brett MitchellSchool of Nursing and Health, Avondale University, New South Wales, Australia.
Darshini AytonSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Alisa M HigginsSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Andrew ForbesSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Ricki SpencerPerioperative Medicine Adaptive Platform Trial (PROMPT) Consumer Committee, Melbourne, Australia.
Elizabeth G RyanSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Platform trials are an extremely powerful, cost-effective innovation in clinical trial design and evidence-to-practice translation. As questions are answered progressively, additional new interventions, within the same or new domains, are substituted into the platform. This design is ideal for evaluation of interventions aiming to reduce surgical site infection, which remains the most common serious complication after surgery. Objective: To efficiently identify effective, ineffective, or harmful treatments to reduce the incidence of perioperative infections and other major complications after surgery. Study design: Perioperative medicine adaptive platform trial (PROMPT) is a multicentre, Bayesian adaptive platform trial designed to reach conclusions regarding superiority, efficacy, equivalence, inferiority, harm, or futility. Modules within the protocol include the master protocol, multiple domain-specific appendices, and a statistical appendix. Study population: Adult patients undergoing a broad range of surgical procedures in participating hospitals. Interventions: Specific interventions under study will be described in domain-specific appendices. The first intervention under study is liberal inspired oxygen concentrations during surgery. Outcomes: The primary outcome is the incidence of surgical site infection up to 30 days after index surgery; this will apply to all domains unless otherwise specified in a domain-specific appendix. Secondary outcomes include other health care-associated infections and major postoperative complications up to 30 days after surgery, quality of recovery (QoR-15) at 3 and 30 days after surgery, and days alive and at home up to 30 days after surgery (DAH Conclusions: PROMPT is designed to efficiently evaluate interventions aiming to reduce surgical site infection and other major complications after surgery. Clinical trial registration: NCT07186634. Protocol version number and date: 1.1, December 4, 2025.

Indexed as

anaesthesiaBayesian adaptive platform trialcomplicationsmaster protocolsurgerysurgical site infection

Identifiers

PMID42701421
PMCPMC13545434

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.