Opening threshold and kinetics of the MscL mechanosensitive channel are regulated by its periplasmic loop.

Kingsley C Duru, Paul Rohde, Hooman Hafezi, Omid Bavi, Navid Bavi, Boris Martinac

Abstract read

In one paragraph

Article in npj biological physics and mechanics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

Update of
Opening threshold and kinetics of the MscL mechanosensitive channel are regulated by its periplasmic loop.2026

5 · Who and what money

Authors and funding

6 authors.

Kingsley C Duru *Mechanobiology Laboratory, Victor Chang Cardiac Research Institute, Sydney, NSW Australia.

Paul Rohde *Mechanobiology Laboratory, Victor Chang Cardiac Research Institute, Sydney, NSW Australia.

Hooman Hafezi *Department of Mechanical and Aerospace Engineering, Shiraz University of Technology, Shiraz, Iran.

Omid BaviDepartment of Mechanical and Aerospace Engineering, Shiraz University of Technology, Shiraz, Iran.

Navid BaviDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA USA.

Boris MartinacMechanobiology Laboratory, Victor Chang Cardiac Research Institute, Sydney, NSW Australia.

Funding

Elucidating the gating mechanisms of bacterial mechanosensitive channelsR01GM144581 · NIGMS · ROCKEFELLER UNIVERSITY · PI THOMAS WALZ · 2023 to 2026

$2.0M

NIGMS NIH HHS R01 GM144581

6 · The paper itself

Abstract

Mechanosensitive channels of large conductance (MscL) protect bacteria from hypo-osmotic stress by opening a large pore in response to membrane tension. The transmembrane TM1 and TM2 helices together with the N-terminal amphipathic helix function as the primary force-sensing structural domains, whereas the role of the periplasmic loop in the channel gating remains poorly understood. Using experimental and computational approaches, our study demonstrates that mutating the loop residues (A64, Q65, G66, D67) or inserting a four-glycine flexible hinge at D67 site modified the properties of the channel recorded in giant

Indexed as

BiochemistryBiophysics

Identifiers

PMID42701400

DOI10.1038/s44341-026-00048-4

PMCPMC13545008

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.