Evidence map›Paper›PMID 42701357›Full record

ArticleOphthalmology science2026

Associations of Cone Density and Choroidal Thickness with Age: A Cross-Sectional Study.

Jue Lin, Aixia Yao, Tong Wang, Ning Xu, Shenao Yi, Yang Gao, Ruyu Yan, Jie Ye, Yiyi Wang, Meixiao Shen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jue LinZhejiang Key Laboratory of Ophthalmic Drug Discovery and Medical Device Research, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Aixia YaoThe Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China.
Tong WangZhejiang Key Laboratory of Ophthalmic Drug Discovery and Medical Device Research, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Ning XuZhejiang Key Laboratory of Ophthalmic Drug Discovery and Medical Device Research, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Shenao YiZhejiang Key Laboratory of Ophthalmic Drug Discovery and Medical Device Research, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Yang GaoZhejiang Key Laboratory of Ophthalmic Drug Discovery and Medical Device Research, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Ruyu YanZhejiang Key Laboratory of Ophthalmic Drug Discovery and Medical Device Research, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Jie YeZhejiang Key Laboratory of Ophthalmic Drug Discovery and Medical Device Research, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Yiyi WangZhejiang Key Laboratory of Ophthalmic Drug Discovery and Medical Device Research, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Meixiao ShenZhejiang Key Laboratory of Ophthalmic Drug Discovery and Medical Device Research, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Chenxiao WangZhejiang Key Laboratory of Ophthalmic Drug Discovery and Medical Device Research, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Fan LuZhejiang Key Laboratory of Ophthalmic Drug Discovery and Medical Device Research, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Yilei ShaoZhejiang Key Laboratory of Ophthalmic Drug Discovery and Medical Device Research, Eye Hospital, Wenzhou Medical University, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To investigate the interrelationships among choroidal blood supply, photoreceptor structure, and visual function during normal aging using OCT and adaptive optics (AO). Design: A cross-sectional study. Subjects: A total of 68 participants aged 20-70 years were included in this study. Methods: All enrolled participants underwent a complete ophthalmological examination, including best-corrected visual acuity, axial length, OCT, and AO fundus photography. Photoreceptor images captured by AO imaging were used to calculate the cone density. A choroidal thickness map was obtained from OCT images using a custom algorithm. Main Outcome Measures: Detailed analysis was performed for the differences and correlations among cone density, choroidal thickness, and age. Results: Compared with group 1 (G1, aged 20-34 years), the cone densities of group 3 (G3, aged 50-64 years) and group 4 (G4, aged 65-79 years) were significantly lower at 0.5 mm to 1.1 mm eccentricities (all Conclusions: The cones showed significant correlation with the choroid and age. Reduced choroidal thickness and older age were associated with lower cone density, highlighting the interdependent aging of vascular and structural parameters in age-related visual impairment. Financial Disclosures: The author has no/the authors have no proprietary or commercial interest in any materials discussed in this article.

Indexed as

AgeChoroidal thicknessCone densityVisual acuity

Identifiers

PMID42701357
PMCPMC13545361

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.