Evidence map›Paper›PMID 42701183›Full record

ReviewJournal of hematology & oncology2026

Cytokine fusion proteins for solid tumor therapy: mechanistic insights and clinical advances.

Yufang Wang, Jing Zheng, Zhen Li, Jingjing Qu, Yuqing Ren, Ziwan Cai, Yuekang Li, Wenjia Sun, Nan Jiang, Cuihong Cai and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of hematology & oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yufang WangDepartment of Respiratory Medicine, Thoracic Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, China.
Jing ZhengDepartment of Respiratory Medicine, Thoracic Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, China.
Zhen LiDepartment of Respiratory Medicine, Thoracic Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, China.
Jingjing QuDepartment of Respiratory Medicine, Thoracic Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, China.
Yuqing RenDepartment of Respiratory Medicine, Thoracic Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, China.
Ziwan CaiDepartment of Respiratory Medicine, Thoracic Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, China.
Yuekang LiDepartment of Respiratory Medicine, Thoracic Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, China.
Wenjia SunDepartment of Respiratory Medicine, Thoracic Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, China.
Nan JiangDepartment of Respiratory Medicine, Thoracic Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, China.
Cuihong CaiDepartment of Respiratory Medicine, Thoracic Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, China.
Kexin RuanDepartment of Respiratory Medicine, Thoracic Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, China.
Jiahe ShiDepartment of Respiratory Medicine, Thoracic Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, China.
Zheya ZhangDepartment of Respiratory Medicine, Thoracic Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, China.
Jianya ZhouDepartment of Respiratory Medicine, Thoracic Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, China. zhoujy@zju.edu.cn.

Funding

Zhejiang Province Pioneer Research and Development Project No. 2025C02094Zhejiang Province Pioneer Research and Development Project. No.2025C02092
6 · The paper itself

Abstract

Cytokine fusion proteins are engineered biologics that combine functional modules, such as cytokines, antibodies, or albumin-binding domains, into a single molecular entity. These agents have emerged as promising therapeutic platforms for treating solid tumors. However, their clinical translation remains constrained by the need to achieve potent antitumor activity while mitigating dose-limiting systemic toxicities. Here, we dissect the mechanistic foundations of cytokine fusion protein function by examining key cytokine signaling pathways within the tumor microenvironment. We also provide a comprehensive overview of current engineering strategies and clinical developments, focusing on approaches to optimize pharmacokinetics, enhance tumor-targeted delivery, and achieve therapeutic synergy. Collectively, this Review summarizes the evolving landscape of cytokine fusion protein development and discusses emerging opportunities and challenges that may inform future advances in this field.

Indexed as

Antineoplastic AgentsCytokinesNeoplasmsRecombinant Fusion ProteinsAnimalsHumansSignal TransductionTumor MicroenvironmentAntineoplastic AgentsCytokinesRecombinant Fusion ProteinsCytokineFusion proteinSolid tumorTumor immune microenvironment

Identifiers

PMID42701183
PMCPMC13546519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.