ArticleHistochemistry and cell biology2026
Differences related to sex in adolescent obese Zucker rats: locomotor activity and dendritic arborization of neurons in layer V of the primary motor cortex.
Article in Histochemistry and cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a metabolic disorder characterized by the accumulation of excess body fat, which has been linked to skeletal muscle and motor behavior changes. Despite the high prevalence of obesity among children and adolescents in Mexico, it has mostly been studied using adult obese animal models. The objective of the present study was to analyze open-field locomotor activity and dendritic length and dendritic spine density in layer V pyramidal neurons of the primary motor cortex (M1) in adolescent (60-day-old) obese Zucker diabetic fatty (ZDF) rats of both sexes. Long-Evans (LE) rats were used as the control group. Female ZDF rats exhibited increased body weight, Lee index, and abdominal circumference. In contrast, male ZDF rats showed a shorter body length together with increased Lee index and abdominal circumference. However, ZDF rats of both sexes displayed elevated triglyceride and cholesterol levels. In addition, hyperglycemia was observed in male ZDF rats. Female ZDF rats showed decreased exploratory activity. The dendritic length of the basilar arbor of M1 neurons was significantly shorter in female and male ZDF rats, with ZDF males exhibiting a smaller basilar arbor than ZDF females. This last result was also observed in the apical arbor of these neurons. There was also a decrease in basilar and apical dendritic spine density in ZDF rats of both sexes. Our results indicate that female ZDF rats show alterations in exploratory behavior and dendritic arborization, whereas ZDF males are affected in terms of dendritic arborization in M1 neurons, which suggests sex differences in the effects of obesity in adolescent Zucker rats.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.