ArticleClinics (Sao Paulo, Brazil)2026
The association between the biomarker D-dimer and thrombosis in vein segment 5 among patients with first episode of deep vein thrombosis.
Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivePrecise anatomical localization of lower extremity Deep Vein Thrombosis (DVT) has been advocated to improve diagnostic characterization and risk stratification beyond the traditional proximal-distal classification. The objective of this study was to examine whether first-episode DVT involving segment 5 veins differs from non-segment 5 DVT with respect to d-dimer levels and clinical characteristics.
methodIn this retrospective observational study at Copenhagen University Hospital-Amager and Hvidovre, Denmark, from March 1st, 2017 to February 28th, 2019, we included patients with first-episode lower extremity DVT admitted to the Emergency Department. Patients were divided into two groups: segment 5 vein thrombosis and non-segment 5 vein thrombosis. Differences in d-dimer levels between the groups were analyzed using unadjusted and adjusted linear regressions models with d-dimer as the dependent variable.
resultsOf 150 patients with a first-episode lower extremity DVT, 147 had available d-dimer measurements. d-dimer levels were significantly higher in patients with segment 5 vein thrombosis than with Non-segment 5 vein thrombosis. In the unadjusted analysis, mean d-dimer levels were 5.2 Fibrinogen Equivalent Units higher (CI: 2.2:9.8, p = 0.012). After adjustment, this difference increased to 6.5 Fibrinogen Equivalent Units (CI: 1.0:13.0, p = 0.041). These findings suggest that Segment 5 vein thrombosis is associated with increased thrombus degradation and a higher inflammatory burden. This may have significant implications for future risk stratification and the clinical management of DVT.
conclusionFirst-episode Segment 5 vein thrombosis was associated with significantly higher d-dimer levels than Non-segment 5 vein thrombosis.
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