ArticlePoultry science2026
Impact of dietary myo-inositol supplements on immune cell distribution and cytokine expression in laying hens of two different strains.
Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Myo-inositol (MI) is involved in the regulation of key immune cell activities, including signaling pathways and cellular processes. Although immune cell distribution and cytokine expression are key determinants of immune competence in laying hens, the potential role of MI in regulating these parameters is largely unexplored. Thus, this study investigated the effects of dietary MI on the immune system of laying hens. At the age of 26 wk, corresponding to the peak laying period, 40 Lohmann Brown-Classic (LB) and 40 Lohmann LSL-Classic (LSL) hens received a maize-soybean meal-based diet either without (MI0) or with 1 (MI1), 2 (MI2) or 3 (MI3) g supplemented MI/kg feed for 4 wk, resulting in a 2 × 4 factorial design. We measured numbers of various leukocytes in blood, spleen and cecal tonsils, lymphocyte functionality and gene expression of pro- and anti-inflammatory cytokines. Dietary MI supplementation resulted in cell type-, strain- and concentration-specific effects, including increased circulating B cells in LSL hens fed with MI2, reduced splenic B cells in LB hens with MI1 and MI2 and lower CD4
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