Evidence map›Paper›PMID 42700500›Full record

ArticlePoultry science2026

Ferulic acid supplementation in embryonic eggs improves heat resistance of broilers by optimizing thermal manipulation effects.

Nawei Jike, Hanke Wang, Shixiong Lai, Yucai Sun, Yongliang Zhang, Tingting Liu, Fengzhe Chen, Zhichao Hei, Weidong Feng, Kaiqing Rao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nawei JikeKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu, 610041, China.
Hanke WangKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu, 610041, China.
Shixiong LaiKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu, 610041, China; Songtao Saint Laurent Agricultural Technology Company Limited in Guizhou, Tongren Guizhou, 554300, China.
Yucai SunKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu, 610041, China.
Yongliang ZhangKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu, 610041, China.
Tingting LiuKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu, 610041, China.
Fengzhe ChenKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu, 610041, China.
Zhichao HeiKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu, 610041, China.
Weidong FengAnimal Husbandry Research Institute of Ganzi Prefecture, 626000, China.
Kaiqing RaoKey Laboratory of Animal Medicine of Sichuan Education Department, Southwest Minzu University, Chengdu, 610041, China. Electronic address: wkxwzz6@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Embryonic thermal manipulation (TM) enhances heat tolerance in broilers but often reduces hatchability and impairs chick quality. This study investigated the effects of TM combined with soaking embryonic eggs in ferulic acid (FA) solution on the growth performance and heat resistance of broilers. The objective was to optimize the TM regime and clarify the mechanisms by which FA-pretreated TM affects the heat tolerance in growing broilers exposed to heat stress. A total of 1000 fertilized eggs (57 ± 4 g) were randomly divided into three groups: control, TM and TM+FA (soaked in 120 mg/L FA solution from embryonic days 6 to 8). Broilers in the TM and TM + FA groups underwent thermal manipulation from embryonic day 7 to day 16 (10 days) at 39.5 °C and 65% relative humidity for 18 h daily. After hatching, the chicks were reared under standard conditions until 28 days of age, followed by a 2-week chronic cyclic heat stress challenge (35 ± 2 °C, 8 h/d). The results showed that TM+FA improved the hatchability, decreased serum corticosterone levels and feed-to-gain ratio of 28-day-old broilers, and downregulated the gene expression of thyrotropin-releasing hormone (TRH) in the hypothalamus, decreased body temperature of broilers under heat stress (P < 0.05). Both TM and TM+FA alleviated heat-stress-induced liver injury, as evidenced by enhancing antioxidant capacity and decreasing serum alanine aminotransferase activity, and inhibited cardiomyocyte apoptosis via lowering the Bax/Bcl-2 ratio and decreasing HSP90 gene expression (P < 0.05). In conclusion, soaking TM-treated embryonic eggs in FA solution effectively improves the hatchability and heat tolerance of broilers during the post-hatch growth period. Thus, the TM + FA treatment provides a more reliable approach than the single TM treatment to combating heat stress in poultry production.

Indexed as

Antioxidant capacityBroilerEmbryonic thermal manipulationFerulic acidHeat tolerance

Identifiers

PMID42700500
PMCPMC13572520

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.