ArticleFuture science OA2026
A deceptive fungating breast mass: giant fibroadenoma with multiple epidermal inclusion cysts mimicking malignancy.
Article in Future science OA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
aimsTo describe a giant ulcerating fibroadenoma mimicking malignancy and highlight diagnostic uncertainty from discordant clinical, imaging, and biopsy findings. PATIENTS AND
methodsA 22-year-old woman presented with an approximately 10 cm fungating, ulcerated right-breast mass complicated by methicillin-resistant
resultsThe mass was enucleated with preservation of the nipple-areolar complex. Histopathology confirmed giant fibroadenoma with multiple epidermal inclusion cysts, cyst rupture, keratin-associated inflammation, and a foreign-body giant-cell reaction. Earlier biopsy material showed an epidermal component before clinical deterioration. Biopsy-related disruption of this preexisting component, together with inflammation, infection, cyst rupture, and wound breakdown, was considered a possible contributor to the fungating presentation; the exact sequence was uncertain. Histology showed focal superficial-margin involvement at the ulcerated/fungating surface. At six months, there was no clinical or ultrasonographic evidence of recurrence.
conclusionsGiant fibroadenomas may mimic phyllodes tumor or breast malignancy. Clinicoradiological-pathological correlation and multidisciplinary planning can support breast-preserving management despite an alarming presentation when tissue diagnosis remains benign.
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