ArticleThe Journal of physiology2026
Amyloid beta plaque pathology induces chemosensory deficits and increases apnoeas in the 5XFAD mouse model of Alzheimer's disease.
Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Dose-dependent evaluation of chronic oleocanthal on metabolic phenotypes and organ toxicity in 5xFAD mice.Pharmacological research. Natural products · 2025Article
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10 authors.
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Abstract
Sleep disordered breathing (SDB) commonly co-presents with other ventilatory impairments in patients with Alzheimer's disease (AD). Typically reported as either obstructive (OSA) or complex sleep apnoea in AD patients, SDB results in repeated bouts of hypoxia and hypercapnia from insufficient ventilation. It is thought not only that these repeated hypoxic events result in an exacerbation of AD but also that SDB and other ventilatory impairments may be a precursor to neurodegenerative diseases. Although the cause of SDB in AD patients is unclear, chemosensory drive malfunction, a response critical to maintaining homeostatic oxygen and carbon dioxide balance, may play a role. We examined basal ventilation, SDB and chemosensory function in 5XFAD mice, a beta amyloidosis model of AD which displays progressive amyloid beta (Aβ) plaque deposition by 8 months of age. We found that both male and female 5XFAD mice had nearly twice as many spontaneous apnoeas per hour compared to WT mice. Basal ventilation (V̇
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