ArticleMetabolic brain disease2026
L-carnitine modulates molecular responses associated with inflammation, endoplasmic reticulum stress, and neurotrophic signaling in cerebral cortex of neonatal Gcdh
Ediandra Tissot Castro, Ângela Zanatta, Andrey Vinicios Soares Carvalho, Amanda Uggeri de Moraes, Carlos Alexandre Netto, Guilhian Leipnitz, Alexandre Umpierrez Amaral, Carmen Regla Vargas, Rafael Teixeira Ribeiro, Moacir Wajner
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In one paragraphArticle in Metabolic brain disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
Ediandra Tissot CastroPPG Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal de Rio Grande Do Sul, Rua Ramiro Barcelos, 2600, Prédio 21111, Porto Alegre, RS, 90035-003, Brazil.ORCID http://orcid.org/0000-0002-2358-6695 Ângela ZanattaPPG Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal de Rio Grande Do Sul, Rua Ramiro Barcelos, 2600, Prédio 21111, Porto Alegre, RS, 90035-003, Brazil.ORCID http://orcid.org/0000-0001-5648-4997 Andrey Vinicios Soares CarvalhoPPG Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal de Rio Grande Do Sul, Rua Ramiro Barcelos, 2600, Prédio 21111, Porto Alegre, RS, 90035-003, Brazil.ORCID http://orcid.org/0000-0001-6543-668X Amanda Uggeri de MoraesPPG Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal de Rio Grande Do Sul, Rua Ramiro Barcelos, 2600, Prédio 21111, Porto Alegre, RS, 90035-003, Brazil.ORCID http://orcid.org/0009-0002-9849-9454 Carlos Alexandre NettoPPG Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal de Rio Grande Do Sul, Rua Ramiro Barcelos, 2600, Prédio 21111, Porto Alegre, RS, 90035-003, Brazil.ORCID http://orcid.org/0000-0002-0596-5667 Guilhian LeipnitzPPG Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal de Rio Grande Do Sul, Rua Ramiro Barcelos, 2600, Prédio 21111, Porto Alegre, RS, 90035-003, Brazil.ORCID http://orcid.org/0000-0001-7964-8923 Alexandre Umpierrez AmaralPPG Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal de Rio Grande Do Sul, Rua Ramiro Barcelos, 2600, Prédio 21111, Porto Alegre, RS, 90035-003, Brazil.ORCID http://orcid.org/0000-0001-6512-0714 Carmen Regla VargasPPG Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal de Rio Grande Do Sul, Rua Ramiro Barcelos, 2600, Prédio 21111, Porto Alegre, RS, 90035-003, Brazil.ORCID http://orcid.org/0000-0002-2135-0654 Rafael Teixeira RibeiroPPG Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal de Rio Grande Do Sul, Rua Ramiro Barcelos, 2600, Prédio 21111, Porto Alegre, RS, 90035-003, Brazil. rafaeltribeiro@hcpa.edu.br.ORCID http://orcid.org/0000-0001-5814-6369 Moacir WajnerPPG Ciências Biológicas: Bioquímica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal de Rio Grande Do Sul, Rua Ramiro Barcelos, 2600, Prédio 21111, Porto Alegre, RS, 90035-003, Brazil.ORCID http://orcid.org/0000-0001-6372-1807 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Glutaric acidemia type 1 (GA I) is caused by deficient activity of glutaryl-CoA dehydrogenase, leading to predominant accumulation of glutaric acid (GA) in the brain. GA I patients present progressive neurological deterioration whose pathophysiology is only partially elucidated. We investigated whether intracerebral GA administration, alone or combined with quinolinic acid (QA), a pro-inflammatory intermediate of the kynurenine pathway, could alter the expression of genes associated with inflammatory signaling, endoplasmic reticulum (ER) stress, and neurotrophic support in cerebral cortex of wild-type (WT) and Gcdh
Indexed as
Brain Diseases, MetabolicCarnitineCerebral CortexEndoplasmic Reticulum StressGlutaratesGlutaryl-CoA DehydrogenaseInflammationNerve Growth FactorsQuinolinic AcidAmino Acid Metabolism, Inborn ErrorsAnimalsAnimals, NewbornMiceMice, Inbred C57BLMice, KnockoutSignal TransductionCarnitineGlutaratesGlutaryl-CoA DehydrogenaseNerve Growth FactorsQuinolinic AcidCerebral cortexGcdh
−/− miceGlutaric acidInflammatory responseNeurotrophinsQuinolinic acid
Identifiers
PMID42700286
PMCPMC13546310
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